具有最终可逆性的危及生命的博来霉素肺毒性。

Life-threatening bleomycin pulmonary toxicity with ultimate reversibility.

作者信息

Hartmann L C, Frytak S, Richardson R L, Coles D T, Cupps R E

机构信息

Department of Medical Oncology, Mayo Clinic, Rochester, MN.

出版信息

Chest. 1990 Aug;98(2):497-9. doi: 10.1378/chest.98.2.497.

DOI:10.1378/chest.98.2.497

PMID:1695873

Abstract

A 60-year-old man with advanced seminoma was treated with four cycles of a cisplatin, etoposide and bleomycin. He then developed severe pulmonary toxicity with diffuse infiltrates as evidenced on a chest x-ray film. The room air PaO2 value was 32 mm Hg. The patient was treated with steroids and oxygen supplementation, including a high FIo2 for several days, and survived and eventually experienced marked improvement in his pulmonary status. Aggressive management of severe bleomycin-induced pneumonitis appears justified.

摘要

一名60岁的晚期精原细胞瘤男性患者接受了四个周期的顺铂、依托泊苷和博来霉素治疗。随后，他出现了严重的肺部毒性，胸部X光片显示有弥漫性浸润。室内空气下的动脉血氧分压值为32毫米汞柱。该患者接受了类固醇和氧疗，包括数天高吸氧浓度，最终存活下来，肺部状况也显著改善。积极治疗严重的博来霉素诱导的肺炎似乎是合理的。