糖基双卟啉共轭物：合成及其在光动力疗法中的潜在应用
Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.
作者信息
Sol V, Chaleix V, Champavier Y, Granet R, Huang Y-M, Krausz P
机构信息
Université de Limoges - Laboratoire de Chimie des Substances Naturelles 123, Avenue Albert Thomas-87060 Limoges, France.
出版信息
Bioorg Med Chem. 2006 Dec 1;14(23):7745-60. doi: 10.1016/j.bmc.2006.08.004. Epub 2006 Sep 7.
Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.
描述了通过柔性烃链在中位连接的新型糖基化中性和阳离子卟啉二聚体的合成。详细的¹H和¹³C NMR研究使其结构得以完全阐明。还给出了紫外可见光谱、荧光光谱和基质辅助激光解吸电离质谱。将这些化合物对K562白血病细胞系的光细胞毒性与血卟啉衍生物II的光细胞毒性进行了比较。
Zotero 插件