Goldberg R B, Bersohn I, Kew M C
S Afr Med J. 1975 Aug 23;49(36):1464-6.
Hepatic synthesis of cholesterol in higher animals is normally markedly suppressed by dietary cholesterol. This feedback regulation has been shown to be absent in all experimental hepatomas studied, and also in the only 2 humans with primary hepatocellular cancer (PHC) who have been investigated. Another patient who presented with hypercholesterolaemia is described in whom cholesterogenesis in the tumour was not suppressed by cholesterol feeding. In order to determine the frequency with which hypercholesterolaemia occurs in PHC, serum cholesterol levels were measured in 132 Black patients with this tumour. Raised levels were found in 14 of the patients (11%). In only 2 of these was hypercholesterolaemia associated with obstructive jaundice.
在高等动物中，肝脏合成胆固醇的过程通常会受到膳食胆固醇的显著抑制。研究表明，在所有已研究的实验性肝癌中，以及在仅有的2例接受调查的原发性肝细胞癌（PHC）患者中，这种反馈调节均不存在。本文描述了另一位患有高胆固醇血症的患者，其肿瘤中的胆固醇生成并未因喂食胆固醇而受到抑制。为了确定PHC患者中高胆固醇血症的发生频率，对132例患有该肿瘤的黑人患者进行了血清胆固醇水平检测。在14例患者（11%）中发现胆固醇水平升高。其中只有2例高胆固醇血症与梗阻性黄疸相关。
