Tasaki Hirofumi, Serita Takumi, Ueyama Chiaki, Kitano Kouei, Seto Shinji, Yano Katsusuke, Camm A John
Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Int Heart J. 2006 Jul;47(4):549-63. doi: 10.1536/ihj.47.549.
The aim of this study was to conduct a longitudinal follow-up on age-related changes in 24-hour total heart beats (THBs) and total premature beats and their correlations in healthy elderly subjects. In 15 healthy elderly subjects (mean age, 70.0 +/- 4.1, age range at 1st recording, 64 to 80 years, 10 females, 5 males), we conducted Holter monitoring twice at an interval of 15 years and analysed age-related changes in THBs, atrial premature beats (APBs), and ventricular premature beats (VPBs), as well as their correlations. The results indicated that THBs, APBs, and VPBs all significantly increased with age in the healthy elderly subjects at a mean age of 70.0 +/- 4.1 (THB: 91074.1 +/- 11515.3 versus 99457.5 +/- 12131.0; P = 0.0004, APB:119.2 +/- 97.8 versus 884.4 +/- 1193.8; P = 0.0008, VPB: 15.2 +/- 53.6 versus 140.7 +/- 228.9; P = 0.0328). Moreover, we divided the subjects into increase and nonincrease groups based on the age-related changes in APB and VPB for 15 years ([n]; Inc-APB: Noninc-APB = 6 : 9, Inc-VPB: Noninc-VPB = 5 : 10). In the increase groups, premature beats tended to increase in proportion to changes in THBs with age (APB: Y = 207.488 + 0.136 X, r = 0.848, P = 0.0303; VPB: Y = -27.594 + 0.028 X, r = 0.727, P = 0.1921). In conclusion, this 15-year follow-up of Holter recordings in healthy elderly subjects revealed that THBs, APBs, and VPBs increased with age, and that the increases in premature beats, especially APBs, were in proportion to those in THBs.
本研究旨在对健康老年受试者24小时总心跳数（THBs）和早搏总数的年龄相关变化及其相关性进行纵向随访。在15名健康老年受试者（平均年龄70.0±4.1岁，首次记录时年龄范围为64至80岁，女性10名，男性5名）中，我们每隔15年进行两次动态心电图监测，并分析THBs、房性早搏（APBs）和室性早搏（VPBs）的年龄相关变化及其相关性。结果表明，在平均年龄为70.0±4.1岁的健康老年受试者中，THBs、APBs和VPBs均随年龄显著增加（THB：91074.1±11515.3对99457.5±12131.0；P = 0.0004，APB：119.2±97.8对884.4±1193.8；P = 0.0008，VPB：15.2±53.6对140.7±228.9；P = 0.0328）。此外，我们根据APB和VPB 15年的年龄相关变化将受试者分为增加组和非增加组（[n]；增加-APB：非增加-APB = 6 : 9，增加-VPB：非增加-VPB = 5 : 10）。在增加组中，早搏倾向于随着年龄的增长与THBs的变化成比例增加（APB：Y = 207.488 + 0.136X，r = 0.848，P = 0.0303；VPB：Y = -27.594 + 0.028X，r = 0.727，P = 0.1921）。总之，对健康老年受试者进行的这15年动态心电图记录随访显示，THBs、APBs和VPBs随年龄增加，且早搏尤其是APBs的增加与THBs的增加成比例。
