Bouté Véronique, Goyat Isabelle, Denoux Yves, Lacroix Joelle, Marie Brigitte, Michels Jean-J
Department of Senology, Centre François Baclesse, 14076 Caen, Cedex 5, France.
Eur J Radiol. 2006 Nov;60(2):243-9. doi: 10.1016/j.ejrad.2006.08.003. Epub 2006 Sep 7.
Aschoff's center of proliferation (ACP), poses significant problems of differential diagnosis both in imagery and histology with infiltrating carcinoma. Up to now the criteria of Tabar and Dean (classical criteria) are considered as diagnostically relevant.
A retrospective study of 113 cases, enabled us to study their clinical, radiological and histological aspects.
The ACP is a subclinical and seldom palpable entity (12%). The radiological signs of ACP are quite variable. The classical criteria lack specificity and are observed only in 48% of our stellate images. Whereas the frequency of microcalcifications is high (58.5% of the cases), their presence and their type are not predictive of an associated malignancy. The echographic diagnosis of ACP could be made in 55% of the cases but the echographic semiology lacked specificity. We noticed an associated atypical epithelial hyperplasia in 28.5% of the cases, intraductal or lobular in situ carcinoma in 9% and/or a ductal invasive carcinoma in 2% of the cases. Neither tumor size, age of the patients, nor any radiological signs were predictive of such an association.
The classical criteria are not completely reliable and are observed only in half of our stellate images, whereas microcalcifications are often present but are not predictive of an associated malignancy.
阿绍夫增殖中心（ACP）在影像学和组织学上与浸润性癌的鉴别诊断存在重大问题。到目前为止，塔巴尔和迪恩的标准（经典标准）被认为具有诊断相关性。
对113例病例进行回顾性研究，使我们能够研究其临床、放射学和组织学方面。
ACP是一种亚临床且很少能触及的实体（12%）。ACP的放射学征象变化很大。经典标准缺乏特异性，在我们的星芒状影像中仅48%可见。虽然微钙化的发生率很高（58.5%的病例），但其存在和类型并不能预测是否存在相关恶性肿瘤。55%的病例可做出ACP的超声诊断，但超声征象缺乏特异性。我们注意到28.5%的病例伴有非典型上皮增生，9%的病例伴有导管原位癌或小叶原位癌，2%的病例伴有导管浸润癌。肿瘤大小、患者年龄以及任何放射学征象均不能预测这种关联。
经典标准并不完全可靠，在我们的星芒状影像中仅一半可见，而微钙化虽常存在，但不能预测相关恶性肿瘤。
