佛波酯对聚乙烯亚胺和聚烯丙胺诱导的肥大细胞组胺释放的调节作用。
The modulatory effects of phorbol esters on histamine release from mast cells induced by a polyethylenimine and a polyallylamine.
作者信息
Sekino H, Uchida M K, Suzuki-Nishimura T
机构信息
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
出版信息
Gen Pharmacol. 1990;21(4):535-9. doi: 10.1016/0306-3623(90)90710-4.
PMID:1696232
Abstract
- Histamine release from rat peritoneal mast cells induced by polyethylenimine (mol. wt = 600) was inhibited by phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), but not by 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD). 2. Histamine release induced by polyallylamine (mol. wt = 10,000) was enhanced by PMA and PDBu, but not by 4 alpha-PDD. 3. K-252a reduced the inhibitory effect of PMA on histamine release induced by polyethylenimine and its enhancing effect on histamine release by polyallylamine.
摘要
- 十四酰佛波醇-13-乙酸酯（PMA）和佛波醇-12,13-二丁酸酯（PDBu）可抑制聚乙烯亚胺（分子量 = 600）诱导的大鼠腹膜肥大细胞组胺释放，但4α-佛波醇-12,13-二癸酸酯（4α-PDD）无此作用。2. PMA和PDBu可增强聚烯丙胺（分子量 = 10,000）诱导的组胺释放，但4α-PDD无此作用。3. K-252a可降低PMA对聚乙烯亚胺诱导的组胺释放的抑制作用及其对聚烯丙胺诱导的组胺释放的增强作用。
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