Blickstein Isaac
Department of Obstetrics and Gynecology, Kaplan Medical Center, 76100 Rehovot, Israel.
Obstet Gynecol Clin North Am. 2006 Sep;33(3):347-56. doi: 10.1016/j.ogc.2006.05.003.
Thrombophilia, whether inherited or acquired, is one of the hot topics in women's health. Several factors, some of which are specific to the female patient, enhance thrombus formation in the presence of thrombophilia and include oral contraception, hormone replacement therapy, pregnancy, and puerperium. Thrombotic events are not only restricted to venous thromboembolism but also are believed to cause repeated embryonic loss, fetal loss, placental abruption, intrauterine growth restriction, and severe pre-eclampsia. It seems that some thrombophilias, and a combination of thrombophilic factors, carry a greater risk than others for a given adverse outcome. The addition of LMWH to the armamentarium was associated with conceptual change in the practice of anticoagulation. Care should be exercised in the interpretation of various risks and the potential of anticoagulation as a remedy to reduce that risk.
血栓形成倾向，无论是遗传性的还是后天获得性的，都是女性健康领域的热门话题之一。有几个因素会增加血栓形成倾向患者的血栓形成风险，其中一些因素是女性患者特有的，包括口服避孕药、激素替代疗法、怀孕和产褥期。血栓事件不仅限于静脉血栓栓塞，还被认为会导致反复胚胎丢失、胎儿丢失、胎盘早剥、子宫内生长受限和重度子痫前期。似乎某些血栓形成倾向以及血栓形成倾向因素的组合，比其他因素在特定不良结局方面具有更高的风险。低分子肝素加入抗凝治疗手段中与抗凝实践中的观念转变有关。在解读各种风险以及将抗凝作为降低该风险的一种补救措施的潜力时应谨慎行事。
