Department of Obstetrics and Gynaecology, Chair C, High Risk Pregnancy Unit, University of Torino, Torino, Italy.
Ann N Y Acad Sci. 2010 Sep;1205:106-17. doi: 10.1111/j.1749-6632.2010.05674.x.
Both acquired and inherited thrombophilias are associated with an increased risk of pregnancy-related venous thromboembolism (VTE) as well as with adverse pregnancy outcome. However, the extension of attributable risk for each thrombophilia and outcome is still a question of debate. Thrombophilias have been investigated in connection with VTE and pregnancy complications such as: recurrent and nonrecurrent early pregnancy loss, late fetal death, placental abruption, fetal growth restriction, and preeclampsia. This review discusses the evidence of association between thrombophilias and pregnancy outcome together with issues as to clinical management and preventive strategies.
获得性和遗传性血栓形成倾向均与妊娠相关静脉血栓栓塞症（VTE）风险增加以及不良妊娠结局相关。然而，每种血栓形成倾向与结局的归因风险程度仍存在争议。血栓形成倾向与 VTE 以及妊娠并发症如：反复和非反复早期妊娠丢失、晚期胎儿死亡、胎盘早剥、胎儿生长受限和子痫前期等有关。本综述讨论了血栓形成倾向与妊娠结局之间的关联证据，以及临床管理和预防策略方面的问题。
