雌二醇、雷洛昔芬和染料木黄酮对去卵巢小鼠子宫的比较作用。

Comparative effects of estradiol, raloxifene, and genistein on the uterus of ovariectomized mice.

作者信息

García-Pérez Miguel Angel, Noguera Rosa, del Val Raquel, Noguera Inmaculada, Hermenegildo Carlos, Cano Antonio

机构信息

Research Unit, Hospital Clínico Universitario of Valencia, Valencia, Spain.

出版信息

Fertil Steril. 2006 Oct;86(4):1003-5. doi: 10.1016/j.fertnstert.2006.03.029. Epub 2006 Sep 11.

DOI:10.1016/j.fertnstert.2006.03.029

PMID:16963036

Abstract

To explore the uterine effects of administration of compounds that exert their bone-sparing functions through estrogen receptors, we administered 17beta-E2, raloxifene, or genistein to ovariectomized mice and analyzed the uterus weight and histology 4 weeks after beginning the treatments. Results indicated that raloxifene and genistein have partial agonistic properties on the uterus in estrogen-depleted mice, and that genistein induced apoptosis and several atypias in the glandular epithelium of endometrium, as demonstrated in hematoxylin-eosin-stained histological sections.

摘要

为了探究通过雌激素受体发挥骨保护作用的化合物对子宫的影响，我们给去卵巢小鼠施用了17β-雌二醇、雷洛昔芬或染料木黄酮，并在开始治疗4周后分析子宫重量和组织学。结果表明，雷洛昔芬和染料木黄酮对雌激素缺乏小鼠的子宫具有部分激动特性，并且如苏木精-伊红染色组织切片所示，染料木黄酮诱导子宫内膜腺上皮细胞凋亡和几种异型性改变。