孕早期子宫动脉多普勒指数与母体血清游离β-人绒毛膜促性腺激素及妊娠相关血浆蛋白A之间的相关性

Correlation between first-trimester uterine artery Doppler indices and maternal serum free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A.

作者信息

Prefumo Federico, Canini Silvana, Casagrande Valentina, Pastorino Daniela, Venturini Pier Luigi, De Biasio Pierangela

机构信息

Unità Operativa Ostetricia e Ginecologia, Istituto G. Gaslini, Università di Genova, Genoa, Italy.

出版信息

Fertil Steril. 2006 Oct;86(4):977-80. doi: 10.1016/j.fertnstert.2006.01.063. Epub 2006 Sep 11.

DOI:10.1016/j.fertnstert.2006.01.063

PMID:16963045

Abstract

OBJECTIVE

To assess the correlation between first-trimester uterine artery Doppler measurements and maternal serum levels of free beta-hCG and pregnancy-associated plasma protein A (PAPP-A).

DESIGN

Observational study.

SETTING

Teaching hospital.

PATIENT(S): Four hundred thirty-three women at 10-14 weeks of gestation.

INTERVENTION(S): Doppler ultrasound of the uterine arteries. Fluorimetric immunoassays for free beta-hCG and PAPP-A.

MAIN OUTCOME MEASURE(S): Uterine artery mean resistance index (RI), pulsatility index (PI), and number of early diastolic notches. Maternal serum levels of free beta-hCG and PAPP-A.

RESULT(S): There were 401 uncomplicated pregnancies. In this group, free beta-hCG and PAPP-A did not significantly correlate with uterine artery RI or PI (r values between -0.089 and 0.029, all nonsignificant). Free beta-hCG and PAPP-A levels did not significantly change with the number of notches. Uterine artery resistance and PAPP-A levels were independently correlated with birth weight.

CONCLUSION(S): Preliminary evidence suggests that first-trimester uterine artery Doppler measurements do not correlate with maternal serum levels of free beta-hCG and PAPP-A. This may allow their combined use in multivariate screening for pregnancy complications.

摘要