Beheshti M, Khorsand A, Graf S, Dobrozemsky G, Oezer S, Kletter K, Dudczak R, Pirich C
Department of Nuclear Medicine and Endocrinology, PET CT Centre, St. Vincent's Hospital Linz, Seilerstaette 4, 4010 Linz, Austria.
Nuklearmedizin. 2006;45(4):163-70.
Metabolic imaging with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) is actually considered as the best method to detect and quantitatively assess myocardial tissue viability. The aim of this study was to investigate the accuracy of FDG gamma camera positron emission tomography (GCPET) imaging equipped with one inch NaI crystals in comparison to FDG dedicated PET (dPET) imaging as a "gold standard" in phantom and clinical studies.
PATIENTS, METHODS: Nineteen patients with coronary artery disease (CAD) underwent both imaging modalities. Phantom and clinical GCPET imaging were performed with a dual-headed, coincidence based gamma camera equipped with 1 inch thick NaI crystals and an x-ray tube (XCT) for attenuation correction (AC), as well as with a dedicated PET scanner with AC. (99m)Tc tetrofosmin single-photon emission tomography (SPET) studies were performed for assessment of myocardial perfusion, with AC.
Phantom studies showed a significant relation in segmental activity between FDG imaging with AC using GCPET and dPET (r = 0.91, p < 0.001). In clinical studies with AC correlation coefficients of mean segmental FDG uptake and regional defect size were r = 0.87 (p < 0.0001) and r = 0.83 (p < 0.0001), respectively. In regional analysis close agreement was even found in the most attenuated regions of the heart if AC was used in GCPET imaging. The overall agreement for detection of viable myocardium was 81% between FDG-dPET (AC) and FDG-GCPET (AC) and 74% between FDG-dPET (AC) and FDG-GCPET (NC).
This study suggests that the assessment of myocardial metabolism by means of FDG is feasible with a coincidence based gamma camera equipped with 1 inch thick NaI crystals if AC is performed. The results reveal a close concordance and agreement between FDG-dPET (AC) and FDG-GCPET (AC) as compared to FDG-GCPET (NC).
使用2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）进行代谢成像实际上被认为是检测和定量评估心肌组织活力的最佳方法。本研究的目的是在体模和临床研究中，将配备1英寸碘化钠晶体的FDGγ相机正电子发射断层扫描（GCPET）成像与作为“金标准”的FDG专用PET（dPET）成像的准确性进行比较。
患者、方法：19例冠状动脉疾病（CAD）患者接受了两种成像模式检查。体模和临床GCPET成像使用配备1英寸厚碘化钠晶体和X射线管（XCT）进行衰减校正（AC）的双头符合γ相机，以及配备AC的专用PET扫描仪进行。进行（99m）锝替曲膦单光子发射断层扫描（SPET）研究以评估心肌灌注，并进行AC。
体模研究显示，使用GCPET和dPET进行AC的FDG成像之间的节段活性存在显著相关性（r = 0.91，p < 0.001）。在进行AC的临床研究中，平均节段FDG摄取与区域缺损大小的相关系数分别为r = 0.87（p < 0.0001）和r = 0.83（p < 0.0001）。在区域分析中，如果在GCPET成像中使用AC，即使在心脏衰减最严重的区域也发现了高度一致性。FDG-dPET（AC）与FDG-GCPET（AC）之间检测存活心肌的总体一致性为81%，FDG-dPET（AC）与FDG-GCPET（NC）之间为74%。
本研究表明，如果进行AC，使用配备1英寸厚碘化钠晶体的符合γ相机通过FDG评估心肌代谢是可行的。结果显示，与FDG-GCPET（NC）相比，FDG-dPET（AC）与FDG-GCPET（AC）之间具有高度的一致性。
