Donoso L A, Gregerson D S, Fling S P, Merryman C F, Sery T W
Retina Service, Wills Eye Hospital, Philadelphia, PA.
Curr Eye Res. 1990;9 Suppl:155-61. doi: 10.3109/02713689008999436.
S-antigen is a highly pathogenic retinal autoantigen for the induction of experimental autoimmune uveitis (EAU). EAU is predominantly a T cell mediated autoimmune disease of the uveal tract and retina of the eye and the pinealocytes of the pineal gland. Using synthetic peptides it has been possible to identify several B cell and T cell epitopes in the molecule. In addition, synthetic peptides derived from proteins of diverse origin with amino acid sequence homology to pathogenic regions of S-antigen induce an EAU which is indistinguishable from the disease induced by native S-antigen. These studies aid in the understanding of immune mechanisms in EAU and provide a basis for the pathogenesis of uveitis in humans.
S抗原是一种用于诱导实验性自身免疫性葡萄膜炎（EAU）的高致病性视网膜自身抗原。EAU主要是一种由T细胞介导的眼部葡萄膜、视网膜以及松果体松果体细胞的自身免疫性疾病。利用合成肽已能够鉴定该分子中的几个B细胞和T细胞表位。此外，源自不同来源蛋白质且与S抗原致病区域具有氨基酸序列同源性的合成肽可诱导出与天然S抗原诱导的疾病难以区分的EAU。这些研究有助于理解EAU中的免疫机制，并为人类葡萄膜炎的发病机制提供依据。
