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龈下刮治术和根面平整术联合洗必泰漱口水治疗慢性牙周炎:一项随机、安慰剂对照临床试验

Scaling and root planing and chlorhexidine mouthrinses in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial.

作者信息

Faveri Marcelo, Gursky Lauren Christine, Feres Magda, Shibli Jamil Awad, Salvador Sergio Luiz, de Figueiredo Luciene Cristina

机构信息

Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.

出版信息

J Clin Periodontol. 2006 Nov;33(11):819-28. doi: 10.1111/j.1600-051X.2006.00994.x. Epub 2006 Sep 11.

Abstract

OBJECTIVE

Evaluation of the clinical and microbiological effects of scaling and root planing (SRP) alone or in combination with 0.12% chlorhexidine (CHX) rinsing.

METHODS

A blind, placebo-controlled, parallel-design, randomized clinical trial was conducted in 29 subjects with chronic periodontitis. Subjects were assigned to two therapeutic groups: control (SRP+placebo) and test (SRP+CHX during and up to 42 days post-therapy). Clinical and microbiological [N-benzoyl-dl-arginine-2-naphthylamide (BANA test)] examinations were performed at baseline, 42 and 63 days post-therapy.

RESULTS

Initially, intermediate sites (4-6 mm) in the test group showed less plaque accumulation, gingival bleeding, bleeding on probing and a greater reduction in attachment level and probing depth (PD) at 63 days after treatment. The initially deep sites (>6 mm) in the CHX group also showed a better reduction in plaque accumulation and in PD compared with the control group. Both therapies led to a microbiological improvement; however, the test subjects showed a higher frequency of BANA-negative sites after treatment, which was sustained over time (p<0.001). At 63 days, the control group presented 25 BANA-negative sites and 65 positive sites, and the test group 58 and 26, respectively.

CONCLUSION

The combination of CHX rinses and SRP leads to clinical benefits and to a better reduction in BANA-positive species.

摘要

目的

评估单纯龈下刮治术和根面平整术(SRP)或联合0.12%氯己定(CHX)冲洗的临床和微生物学效果。

方法

对29例慢性牙周炎患者进行了一项盲法、安慰剂对照、平行设计的随机临床试验。受试者被分为两个治疗组:对照组(SRP+安慰剂)和试验组(治疗期间及治疗后42天内使用SRP+CHX)。在基线、治疗后42天和63天进行临床和微生物学检查[N-苯甲酰-dl-精氨酸-2-萘酰胺(BANA试验)]。

结果

最初,试验组的中度位点(4-6毫米)在治疗后63天菌斑堆积、牙龈出血、探诊出血较少,附着水平和探诊深度(PD)降低更明显。与对照组相比,CHX组最初的深度位点(>6毫米)在菌斑堆积和PD方面也有更好的降低。两种治疗方法均导致微生物学改善;然而,试验组治疗后BANA阴性位点的频率更高,且随时间持续存在(p<0.001)。在63天时,对照组有25个BANA阴性位点和65个阳性位点,试验组分别为58个和26个。

结论

CHX冲洗与SRP联合使用可带来临床益处,并能更好地减少BANA阳性菌。

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