Faveri Marcelo, Gursky Lauren Christine, Feres Magda, Shibli Jamil Awad, Salvador Sergio Luiz, de Figueiredo Luciene Cristina
Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil.
J Clin Periodontol. 2006 Nov;33(11):819-28. doi: 10.1111/j.1600-051X.2006.00994.x. Epub 2006 Sep 11.
Evaluation of the clinical and microbiological effects of scaling and root planing (SRP) alone or in combination with 0.12% chlorhexidine (CHX) rinsing.
A blind, placebo-controlled, parallel-design, randomized clinical trial was conducted in 29 subjects with chronic periodontitis. Subjects were assigned to two therapeutic groups: control (SRP+placebo) and test (SRP+CHX during and up to 42 days post-therapy). Clinical and microbiological [N-benzoyl-dl-arginine-2-naphthylamide (BANA test)] examinations were performed at baseline, 42 and 63 days post-therapy.
Initially, intermediate sites (4-6 mm) in the test group showed less plaque accumulation, gingival bleeding, bleeding on probing and a greater reduction in attachment level and probing depth (PD) at 63 days after treatment. The initially deep sites (>6 mm) in the CHX group also showed a better reduction in plaque accumulation and in PD compared with the control group. Both therapies led to a microbiological improvement; however, the test subjects showed a higher frequency of BANA-negative sites after treatment, which was sustained over time (p<0.001). At 63 days, the control group presented 25 BANA-negative sites and 65 positive sites, and the test group 58 and 26, respectively.
The combination of CHX rinses and SRP leads to clinical benefits and to a better reduction in BANA-positive species.
评估单纯龈下刮治术和根面平整术(SRP)或联合0.12%氯己定(CHX)冲洗的临床和微生物学效果。
对29例慢性牙周炎患者进行了一项盲法、安慰剂对照、平行设计的随机临床试验。受试者被分为两个治疗组:对照组(SRP+安慰剂)和试验组(治疗期间及治疗后42天内使用SRP+CHX)。在基线、治疗后42天和63天进行临床和微生物学检查[N-苯甲酰-dl-精氨酸-2-萘酰胺(BANA试验)]。
最初,试验组的中度位点(4-6毫米)在治疗后63天菌斑堆积、牙龈出血、探诊出血较少,附着水平和探诊深度(PD)降低更明显。与对照组相比,CHX组最初的深度位点(>6毫米)在菌斑堆积和PD方面也有更好的降低。两种治疗方法均导致微生物学改善;然而,试验组治疗后BANA阴性位点的频率更高,且随时间持续存在(p<0.001)。在63天时,对照组有25个BANA阴性位点和65个阳性位点,试验组分别为58个和26个。
CHX冲洗与SRP联合使用可带来临床益处,并能更好地减少BANA阳性菌。