电耦合是自由活动猫中θ节律的基础。

Electrical coupling underlies theta rhythm in freely moving cats.

作者信息

Gołebiewski Henryk, Eckersdorf Barbara, Konopacki Jan

机构信息

Department of Neurobiology, The University of Łódź, Łódź, 90-222, Rewolucji 1905 no. 66, Poland.

出版信息

Eur J Neurosci. 2006 Sep;24(6):1759-70. doi: 10.1111/j.1460-9568.2006.04993.x. Epub 2006 Sep 8.

DOI:10.1111/j.1460-9568.2006.04993.x

PMID:16965552

Abstract

The role of gap junction coupling in the generation of theta rhythms in freely moving cats was investigated in a present study. Two gap junction blockers, carbenoxolone and quinine, were administered intraperitoneally and intrahippocampally; both gap junction blockers abolished or diminished (respectively) hippocampal formation theta. The inhibitory effect developed approximately 30 min after drug administration. This effect was found to be reversible. Our results provide the first direct in vivo evidence for the contribution of gap junction communication in mechanisms of neural synchrony, underlying the production of theta in in vivo conditions.

摘要

在本研究中，我们调查了缝隙连接耦合在自由活动猫的θ节律产生中的作用。两种缝隙连接阻滞剂，即生胃酮和奎宁，分别通过腹腔注射和海马内注射给药；两种缝隙连接阻滞剂均消除或减弱了（分别）海马结构的θ节律。抑制作用在给药后约30分钟出现。发现这种作用是可逆的。我们的结果为缝隙连接通讯在神经同步机制中的作用提供了首个直接的体内证据，而神经同步是体内条件下θ节律产生的基础。