Rockstroh Brigitte, Junghöfer Markus, Elbert Thomas, Buodo Giulia, Miller Gregory A
Department of Psychology, University of Konstanz, Konstanz, Germany.
Psychophysiology. 2006 Sep;43(5):431-9. doi: 10.1111/j.1469-8986.2006.00424.x.
Schizophrenia is typically associated with cognitive deficits, but symptoms also point to alterations in the processing of affective material, with potential impact on behavioral performance. This impact may unfold on multiple time scales, but initial processing of rapidly unfolding social cues may be particularly important. MEG-assessed regional brain activity associated with the capacity to process the emotional content of rapid visual stimuli (3/s) was examined in 12 individuals with schizophrenia and 12 matched controls. Patients showed less differentiation of emotional versus neutral stimuli 90-300 ms following picture onset. Together with group differences in the lateral topography of valence effects, these results are discussed as evidence of deficient automatic processing of emotionally potent stimuli in schizophrenia.
精神分裂症通常与认知缺陷有关，但症状也表明情感材料处理存在改变，这可能对行为表现产生潜在影响。这种影响可能在多个时间尺度上显现，但对快速呈现的社交线索的初始处理可能尤为重要。我们对12名精神分裂症患者和12名匹配的对照组进行了研究，通过脑磁图（MEG）评估与处理快速视觉刺激（每秒3次）的情感内容能力相关的区域脑活动。患者在图片呈现后90 - 300毫秒内，对情感刺激与中性刺激的区分较少。结合效价效应在侧部地形图上的组间差异，这些结果被视为精神分裂症患者对情感强烈刺激的自动处理不足的证据进行讨论。
