Zhu Jin-Shui, Song Ming-Quan, Wang Long, Sun Qun, Zhu Li, Fang Chun
Department of Gastroenterology, Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
Zhong Xi Yi Jie He Xue Bao. 2006 Sep;4(5):478-81. doi: 10.3736/jcim20060507.
To investigate the immunoregulation and short-term therapeutic effects of super-selective intra-arterial chemotherapy combined with Fuzheng Kang'ai Granules, a compound Chinese herbal medicine, on patients with late gastric cancer.
Forty patients with late gastric antrum cancer were randomly divided into study group and control group. Patients in the study group were orally administered Fuzheng Kang'ai Granules 48 hours after the first super-selective left gastric artery chemotherapy with high-dose drugs (EAP regime: VP(16) 100 mg/m(2) + epirubicin 60 mg/m(2) + carboplatin 200 mg/m(2)), while patients in the control group were only administered the same local artery chemotherapy as in the study group.
The short-term therapeutic efficacy in the study group and control group were 82.5% and 57.5% respectively (P<0.01). The occurrence rates of side effects in the study group were significantly lower than those in the control group (P<0.01). The Karnofsky score of life quality of the study group was obviously higher than that of the control group after treatment (P<0.05). The half survival time and one year survival rate in the study group and control group were (24.9 +/- 1.36) month, 70% (28/40) and (13.7 +/- 0.72) month, 35% (14/40) respectively. They were significantly improved in the study group compared with the control group (P<0.01). The levels of cytokines interleukin 2 (IL-2), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma) after treatment in the study group were significantly higher than those before treatment (P<0.05 or P<0.01), as well as than those after treatment in the control group (P<0.01). On the other hand, the level of immune inhibitory factor soluble interleukin-2 receptor (sIL-2R) after treatment in the study group was lower than that before treatment, as well as than that after treatment in the control group (P<0.01).
The super-selective intra-arterial chemotherapy combined with Fuzheng Kang'ai Granules has good short-term therapeutic efficiency and few side effects for patients with late gastric antrum cancer. It can significantly improve the life quality, extend the survival period, and improve the survival rate in patients with late gastric antrum cancer, which may be due to the up-regulation of the immune regulating factors such as IL-2, TNF-alpha, IFN-gamma and down-regulation of the immune inhibitory factor sIL-2R.
探讨超选择性动脉内化疗联合复方中药扶正抗癌颗粒对晚期胃癌患者的免疫调节作用及短期治疗效果。
40例晚期胃窦癌患者随机分为研究组和对照组。研究组患者在首次采用高剂量药物（EAP方案：足叶乙甙100mg/m²+表柔比星60mg/m²+卡铂200mg/m²）进行超选择性左胃动脉化疗48小时后口服扶正抗癌颗粒，而对照组患者仅接受与研究组相同的局部动脉化疗。
研究组和对照组的短期治疗有效率分别为82.5%和57.5%（P<0.01）。研究组副作用发生率明显低于对照组（P<0.01）。治疗后研究组生活质量的卡氏评分明显高于对照组（P<0.05）。研究组和对照组的中位生存时间及1年生存率分别为（24.9±1.36）个月、70%（28/40）和（13.7±0.72）个月、35%（14/40）。与对照组相比，研究组明显改善（P<0.01）。研究组治疗后细胞因子白细胞介素2（IL-2）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）水平明显高于治疗前（P<0.05或P<0.01），也高于对照组治疗后（P<0.01）。另一方面，研究组治疗后免疫抑制因子可溶性白细胞介素-2受体（sIL-2R）水平低于治疗前，也低于对照组治疗后（P<0.01）。
超选择性动脉内化疗联合扶正抗癌颗粒对晚期胃窦癌患者具有良好的短期治疗效果且副作用少。它可显著提高晚期胃窦癌患者的生活质量、延长生存期并提高生存率，这可能是由于上调了IL-2、TNF-α、IFN-γ等免疫调节因子以及下调了免疫抑制因子sIL-2R。
