Isoniemi H, Kurki T, Tenovuo O, Kairisto V, Portin R
Department of Neurology, Turku University Central Hospital, Turku, Finland.
Neurology. 2006 Sep 12;67(5):756-60. doi: 10.1212/01.wnl.0000234140.64954.12.
To examine the association between hippocampal volumes, general brain atrophy, and apolipoprotein E (APOE) polymorphism in patients with a remote traumatic brain injury (TBI).
MRI-based volumetric analyses of the hippocampus and lateral ventricles were performed in 58 patients with TBI of varying severity on average 31.3 years after the trauma. The APOE genotype was determined using standard methods and correlated with the MRI volumetric measurements.
Hippocampal or lateral ventricle volumes did not differ significantly in those patients with the APOE-epsilon4 allele (APOE4) vs those without this allele.
The APOE-epsilon4 allele was not associated with the development of hippocampal or ventricular atrophy after traumatic brain injury. If the APOE-epsilon4 allele is associated with an unfavorable outcome after traumatic brain injury as proposed, this association may involve mechanisms other than those responsible for the development of brain atrophy.
研究远期创伤性脑损伤（TBI）患者海马体积、全脑萎缩与载脂蛋白E（APOE）多态性之间的关联。
对58例不同严重程度的TBI患者进行基于磁共振成像（MRI）的海马和侧脑室体积分析，这些患者在创伤后平均31.3年接受检查。采用标准方法确定APOE基因型，并将其与MRI体积测量结果进行关联分析。
携带APOE-ε4等位基因（APOE4）的患者与未携带该等位基因的患者相比，海马或侧脑室体积无显著差异。
APOE-ε4等位基因与创伤性脑损伤后海马或脑室萎缩的发生无关。如果如前所述，APOE-ε4等位基因与创伤性脑损伤后的不良预后相关，那么这种关联可能涉及除脑萎缩发生机制之外的其他机制。
