Iskander Gaby A P, Nelson R Scott, Morehouse Dan L, Tenquist Jane E, Szlabick Randolph E
Department of General Surgery, Marshfield Clinic, Marshfield, Wisconsin 54449, USA.
J Trauma. 2006 Sep;61(3):695-700. doi: 10.1097/01.ta.0000210453.70742.7f.
The incidence and propagation of thrombosis involving vessels distal to the popliteal vein has not been clearly defined in trauma patients. Our aim was to determine the incidence and rate of propagation of infrageniculate deep venous thrombosis (DVT) in a trauma population and identify potential risk factors specific to propagation.
Retrospective review of all trauma admissions between the years 2001 and 2003 was conducted. Only those 18 years or older with an isolated infrageniculate DVT who underwent a lower extremity venous duplex scan during admission were included in the study. Nature of injury, injury severity score (ISS), method of DVT prophylaxis, thrombus location, and risk factors for hypercoagulable states were recorded.
During the study period, 698 trauma admissions were included, and 109 (15.7%) with infrageniculate DVT were identified. Thirty-nine (35.7%) had thrombus propagation (14 suprageniculate and 25 infrageniculate) with a mean ISS of 27.6. Seventy (64.3%) had infrageniculate DVT without propagation and a mean ISS of 19.6. Thirty-eight (97%) patients with propagating infrageniculate DVT had received mechanical prophylaxis, and 33 (84%) also received chemical prophylaxis. The 14 patients with suprageniculate thrombus propagation were the most severely injured (mean ISS = 35.1). Elevated ISS, operation, age < or =62 years, and intensive care unit admission were positively correlated with propagation of infrageniculate DVT.
The incidence and propagation of infrageniculate DVT in an aggressively prophylaxed trauma population are greater than previously reported. The clinical significance of isolated infrageniculate DVT remains to be determined, but when associated with a multiple injury trauma, the patient may be at risk for future suprageniculate DVT formation and may benefit from therapeutic anticoagulation.
创伤患者中,累及腘静脉远端血管的血栓形成发生率及蔓延情况尚未明确界定。我们的目的是确定创伤人群中膝下深静脉血栓形成(DVT)的发生率及蔓延速率,并识别特定于蔓延的潜在风险因素。
对2001年至2003年间所有创伤入院患者进行回顾性研究。仅纳入18岁及以上、入院期间接受下肢静脉双功超声扫描且孤立性膝下DVT的患者。记录损伤性质、损伤严重程度评分(ISS)、DVT预防方法、血栓位置及高凝状态的风险因素。
研究期间,纳入698例创伤入院患者,其中109例(15.7%)确诊为膝下DVT。39例(35.7%)发生血栓蔓延(14例累及膝上,25例累及膝下),平均ISS为27.6。70例(64.3%)膝下DVT未蔓延,平均ISS为19.6。38例(97%)膝下DVT蔓延患者接受了机械预防,33例(84%)还接受了药物预防。14例膝上血栓蔓延患者损伤最严重(平均ISS = 35.1)。ISS升高、手术、年龄≤62岁及入住重症监护病房与膝下DVT蔓延呈正相关。
在积极预防的创伤人群中,膝下DVT的发生率及蔓延情况高于既往报道。孤立性膝下DVT的临床意义尚待确定,但与多发伤相关时,患者未来可能有膝上DVT形成风险,可能从治疗性抗凝中获益。