Sundara Rajan Sujata, Vu Tania Q
Department of Biomedical Engineering, Oregon Health and Science University, Beaverton, Oregon 97006-8921, USA.
Nano Lett. 2006 Sep;6(9):2049-59. doi: 10.1021/nl0612650.
Can quantum dots (QDs) serve as physiologically relevant receptor probes in the interior of cells? We directly visualize endocytosis, redistribution, and shuttling of QD bound-TrkA receptors to PC12 neural processes and far-reaching growth cone tips. Internalized QDs are contained in microtubule-associated vesicles and possess transport properties that reflect TrkA receptor dynamics. This opens up new possibilities for the development of QD platforms as molecular tools to image biochemical signaling and transport cargo in the cell interior.
量子点（QDs）能否作为细胞内部生理相关的受体探针？我们直接观察到与量子点结合的TrkA受体的内吞作用、重新分布以及向PC12神经突起和延伸至远处的生长锥尖端的穿梭。内化的量子点包含在与微管相关的囊泡中，并具有反映TrkA受体动力学的运输特性。这为开发量子点平台作为在细胞内部对生化信号和运输货物进行成像的分子工具开辟了新的可能性。
