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[人粒细胞特异性α2球蛋白的免疫化学鉴定及理化特性]

[Immunochemical identification and physico-chemical characteristics of specific alpha 2 globulin of human granulocytes].

作者信息

Shevchenko O P, Chernova A V, Merkulov A G, Tatarinov Iu S

出版信息

Biull Eksp Biol Med. 1990 Apr;109(4):353-5.

PMID:1696838
Abstract

The antigen which has alpha 2-globulin mobility was identified immunochemically in leukolysate and pus extract. This antigen was localized in polymorphonuclear leukocytes by the immunofluorescence technique in the blood of healthy donors. The alpha 2-globulin of granulocytes (alpha 2GG) is not identical to lactoferrin, lysozyme, granulocyte elastase, fibronectin, fetal hemoglobin, amyloid P-component of the serum. The molecular mass of alpha 2GG is equal to 50 +/- 8 Kd. in the pus extract. The biological role of alpha 2GG is unknown.

摘要

在白细胞溶解产物和脓液提取物中通过免疫化学方法鉴定出具有α2球蛋白迁移率的抗原。利用免疫荧光技术在健康供者血液中,该抗原定位于多形核白细胞中。粒细胞的α2球蛋白(α2GG)与乳铁蛋白、溶菌酶、粒细胞弹性蛋白酶、纤连蛋白、胎儿血红蛋白、血清淀粉样P成分不同。在脓液提取物中,α2GG的分子量等于50±8千道尔顿。α2GG的生物学作用尚不清楚。

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