Khan Salwa, Dickerman Joseph D
Department of Pediatrics, University of Maryland, Suite N5W56 22 S, Greene St, Baltimore, MD 21201, USA.
Thromb J. 2006 Sep 12;4:15. doi: 10.1186/1477-9560-4-15.
Thrombophilia can be defined as a predisposition to form clots inappropriately. Thrombotic events during infancy and childhood are increasingly recognized as a significant source of mortality and morbidity. The predisposition to form clots can arise from genetic factors, acquired changes in the clotting mechanism, or, more commonly, an interaction between genetic and acquired factors. Since the turn of the last century, there has been extensive research focusing on both the genetic and acquired causes of thrombophilia, with particular focus on clotting events in the venous circulation. This review describes clinically relevant aspects of genetic venous thrombophilia, which include well-established, lesser known, and suggested causes of inherited thrombophilias.
易栓症可定义为易于不适当形成血栓的一种倾向。婴儿期和儿童期的血栓形成事件日益被视为死亡和发病的一个重要来源。形成血栓的倾向可能源于遗传因素、凝血机制的后天改变，或者更常见的是遗传因素与后天因素之间的相互作用。自上世纪之交以来，人们对易栓症的遗传和后天病因进行了广泛研究，尤其关注静脉循环中的凝血事件。本综述描述了遗传性静脉易栓症的临床相关方面，其中包括已明确的、鲜为人知的以及推测的遗传性易栓症病因。
