Sakai Tetsuro
Department of Physiology, University of the Ryukyus School of Medicine, Nishihara, Okinawa, 903-0215, Japan.
J Physiol Sci. 2006 Oct;56(5):385-8. doi: 10.2170/physiolsci.SC009206. Epub 2006 Sep 14.
We used cytochalasin D to reduce contraction-related optical signals by inhibiting muscle contraction for the optical monitoring of action potentials, using a voltage-sensitive dye in isolated rat atrium preparations. The suppression of contraction-related signals was so strong that we concluded that this chemical is suitable for this purpose.
我们使用细胞松弛素D,通过抑制肌肉收缩来减少与收缩相关的光学信号,以便在离体大鼠心房标本中使用电压敏感染料对动作电位进行光学监测。对与收缩相关信号的抑制作用非常强烈,以至于我们得出结论,这种化学物质适用于此目的。