Hoogerwerf Willemijntje A
Department of Internal Medicine, Division of Gastroenterology, The University of Michigan, 1500 East Medical Center Drive, 3912 Taubman Center, Ann Arbor, MI 48109-0362, USA.
Curr Gastroenterol Rep. 2006 Oct;8(5):353-9. doi: 10.1007/s11894-006-0019-3.
The gastrointestinal tract displays biologic rhythms in basal gastric acid output, epithelial cell proliferation, gastrointestinal motility, and appetite regulation. Furthermore, the development of gastrointestinal complications after administration of aspirin and after chemo- and radiotherapy for metastatic colon cancer depends on the time of administration. Biologic rhythms are driven by so-called clock genes. Thus, it is conceivable that subsets of genes in the gastrointestinal tract are under clock gene control as well. The purpose of this article is to discuss basic concepts in the studies of biologic rhythms, to review examples of biologic rhythms in the gastrointestinal tract, and to discuss examples of gastrointestinal diseases in which alterations in biologic rhythms may play a pathogenetic role.
胃肠道在基础胃酸分泌、上皮细胞增殖、胃肠蠕动和食欲调节方面呈现生物节律。此外，服用阿司匹林后以及转移性结肠癌进行化疗和放疗后胃肠道并发症的发生取决于给药时间。生物节律由所谓的时钟基因驱动。因此，可以想象胃肠道中的基因子集也受时钟基因控制。本文的目的是讨论生物节律研究中的基本概念，回顾胃肠道生物节律的实例，并讨论生物节律改变可能起致病作用的胃肠道疾病实例。
