Department of Internal Medicine, Division of Gastroenterology, VA Ann Arbor Healthcare System, University of Michigan, 2215 Fuller Road, Ann Arbor, MI 48105, USA.
Rev Endocr Metab Disord. 2009 Dec;10(4):293-300. doi: 10.1007/s11154-009-9119-3.
The molecular basis for biological rhythms is formed by clock genes. Clock genes are functional in the liver, within gastrointestinal epithelial cells and neurons of the enteric nervous system. These observations suggest a possible role for clock genes in various circadian functions of the liver and the gastrointestinal tract through the modulation of organ specific clock-controlled genes. Consequently, disruptions in circadian rhythmicity may lead to adverse health consequences. This review will focus on the current understanding of the role of circadian rhythms in the pathogenesis of gastrointestinal- and hepatic disease such as obesity, non-alcoholic fatty liver disease, alcoholic fatty liver disease and alterations in colonic motility.
生物钟基因构成了生物节律的分子基础。生物钟基因在肝脏、胃肠道上皮细胞和肠神经系统神经元中具有功能。这些观察结果表明，生物钟基因可能通过调节器官特异性时钟控制基因，在肝脏和胃肠道的各种昼夜节律功能中发挥作用。因此，昼夜节律紊乱可能导致不良的健康后果。本综述将重点介绍目前对昼夜节律在胃肠道和肝脏疾病发病机制中的作用的理解，如肥胖、非酒精性脂肪肝疾病、酒精性脂肪肝疾病和结肠运动改变。
