[The anti-allergic activity and mechanism of action of gamma-carboline derivatives].

The antianaphylactic effect of new antihistaminic agents by derivatives of gamma-carboline dimebon and meraboin was studied by the method of passive cutaneous anaphylaxis. It was found that the agents in a dose amounting to 10% of LD50 possessed a high anaphylactic activity which did not correlate with the degree of their antihistaminic effect. During in vitro experiments the mechanism of action of dimebon and meraboin can be conditioned also by their ability to decrease histamine release from mast cells and to reduce the activity of cAMP-dependent phosphodiesterase.