Kirk Allan D
Transplantation. 2006 Sep 15;82(5):593-602. doi: 10.1097/01.tp.0000234905.56926.7f.
Induction immunosuppression is intense, prophylactic therapy used at the time of transplantation based on the empiric observation that more powerful immunosuppression is required to prevent acute rejection early. In the past decade, there has been a growing trend towards the use of specialized agents such as antibody therapies for induction. In general, these agents have been shown to reduce the rate of acute rejection. However, their use has not been clearly shown to improve long-term transplant outcomes. This overview will review the biological basis for induction immunosuppression and the mechanisms of action of those specialized induction agents currently in clinical use. Clinical trials investigating induction regimens will be evaluated, and an individualized approach to the use of induction immunosuppressants will be presented.
诱导免疫抑制是一种强效的预防性治疗，在移植时使用，这是基于经验观察得出的，即早期需要更强有力的免疫抑制来预防急性排斥反应。在过去十年中，使用诸如抗体疗法等特殊药物进行诱导的趋势日益增长。总体而言，这些药物已被证明可降低急性排斥反应的发生率。然而，尚未明确表明它们的使用能改善移植的长期结局。本综述将回顾诱导免疫抑制的生物学基础以及目前临床使用的那些特殊诱导药物的作用机制。将评估研究诱导方案的临床试验，并提出使用诱导免疫抑制剂的个体化方法。
