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1
Immunological crossreactivity between the human immunodeficiency virus type 1 virion infectivity factor and a 170-kD surface antigen of Schistosoma mansoni.1型人类免疫缺陷病毒病毒体感染因子与曼氏血吸虫170-kD表面抗原之间的免疫交叉反应性。
J Exp Med. 1990 Sep 1;172(3):1001-4. doi: 10.1084/jem.172.3.1001.
2
Molecular characterization of two Schistosoma mansoni proteins sharing common motifs with the vif protein of HIV-1.两种与HIV-1病毒vif蛋白具有共同基序的曼氏血吸虫蛋白的分子特征分析
Parasitology. 1994 Jun;108 ( Pt 5):533-42. doi: 10.1017/s0031182000077404.
3
Protective monoclonal antibodies from mice vaccinated or chronically infected with Schistosoma mansoni that recognize the same antigens.来自接种曼氏血吸虫疫苗或慢性感染曼氏血吸虫的小鼠的保护性单克隆抗体，这些抗体识别相同的抗原。
J Immunol. 1987 Dec 1;139(11):3792-801.
4
Antibody to carbohydrate and polypeptide epitopes on the surface of schistosomula of Schistosoma mansoni in Egyptian patients with acute and chronic schistosomiasis.埃及急慢性血吸虫病患者体内针对曼氏血吸虫童虫表面碳水化合物和多肽表位的抗体
Parasitology. 1989 Jun;98 Pt 3:417-24. doi: 10.1017/s0031182000061503.
5
Antibody response against schistosomulum surface antigens and protective immunity following immunization with highly irradiated cercariae of Schistosoma mansoni.曼氏血吸虫高度辐照尾蚴免疫后针对童虫表面抗原的抗体反应及保护性免疫
Parasite Immunol. 1985 Mar;7(2):133-52. doi: 10.1111/j.1365-3024.1985.tb00065.x.
6
Schistosoma mansoni and Biomphalaria glabrata have some common epitopes. I. Common epitopes are present on the surface of early stages of S. mansoni.曼氏血吸虫和光滑双脐螺有一些共同的表位。一、曼氏血吸虫早期阶段的表面存在共同表位。
Comp Biochem Physiol B. 1991;100(3):507-16. doi: 10.1016/0305-0491(91)90212-v.
7
Surface antigen detected by a Schistosoma mansoni monoclonal antibody in worm extracts and kidney deposits of infected mice and hamsters.曼氏血吸虫单克隆抗体在受感染小鼠和仓鼠的虫体提取物及肾脏沉积物中检测到的表面抗原。
Infect Immun. 1986 Apr;52(1):230-5. doi: 10.1128/iai.52.1.230-235.1986.
8
A major role for carbohydrate epitopes preferentially recognized by chronically infected mice in the determination of Schistosoma mansoni schistosomulum surface antigenicity.慢性感染小鼠优先识别的碳水化合物表位在曼氏血吸虫童虫表面抗原性的决定中起主要作用。
J Immunol. 1986 Dec 1;137(11):3601-7.
9
Sera of Schistosoma japonicum-infected patients cross-react with diagnostic 31/32 kD proteins of S. mansoni.日本血吸虫感染患者的血清与曼氏血吸虫的诊断性31/32 kD蛋白发生交叉反应。
Clin Exp Immunol. 1987 Aug;69(2):291-8.
10
Schistosoma mansoni shares a protective carbohydrate epitope with keyhole limpet hemocyanin.曼氏血吸虫与钥孔戚血蓝蛋白共享一种保护性碳水化合物表位。
J Exp Med. 1987 Mar 1;165(3):865-78. doi: 10.1084/jem.165.3.865.

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Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and in Yi People.免疫功能障碍与人类免疫缺陷病毒和 在彝族人群中的合并感染。
J Immunol Res. 2018 Jul 2;2018:6989717. doi: 10.1155/2018/6989717. eCollection 2018.
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Association of schistosomiasis with false-positive HIV test results in an African adolescent population.在非洲青少年人群中，血吸虫病与 HIV 假阳性检测结果有关。
J Clin Microbiol. 2010 May;48(5):1570-7. doi: 10.1128/JCM.02264-09. Epub 2010 Feb 24.
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Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria.曼氏血吸虫与恶性疟原虫共有的一种新型抗原的鉴定以及对人类血吸虫病和疟疾诱导产生的不同交叉反应性抗体亚类的评估。
Infect Immun. 2006 Jun;74(6):3347-54. doi: 10.1128/IAI.01724-05.
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Characterization of Schistosoma mansoni Sds homologue, a leucine-rich repeat protein that interacts with protein phosphatase type 1 and interrupts a G2/M cell-cycle checkpoint.曼氏血吸虫Sds同源物的特性，一种富含亮氨酸的重复蛋白，它与1型蛋白磷酸酶相互作用并中断G2/M细胞周期检查点。
Biochem J. 2006 Apr 15;395(2):433-41. doi: 10.1042/BJ20051597.
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Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy.与慢性蠕虫感染和人类免疫缺陷病毒感染相关的慢性免疫激活：低反应性和无反应性的作用。
Clin Microbiol Rev. 2004 Oct;17(4):1012-30, table of contents. doi: 10.1128/CMR.17.4.1012-1030.2004.
6
Rapid competitive enzyme-linked immunosorbent assay using a monoclonal antibody reacting with a 15-kilodalton tegumental antigen of Schistosoma mansoni for serodiagnosis of schistosomiasis.使用与曼氏血吸虫15千道尔顿被膜抗原反应的单克隆抗体进行快速竞争性酶联免疫吸附测定以用于血吸虫病的血清学诊断。
J Clin Microbiol. 1993 Sep;31(9):2315-9. doi: 10.1128/jcm.31.9.2315-2319.1993.
7
Immunological changes in cats with concurrent Toxoplasma gondii and feline immunodeficiency virus infections.同时感染弓形虫和猫免疫缺陷病毒的猫的免疫变化。
J Clin Microbiol. 1992 Jan;30(1):17-24. doi: 10.1128/jcm.30.1.17-24.1992.

本文引用的文献

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In vitro and in vivo effector function of rat IgG2a monoclonal anti-S. mansoni antibodies.大鼠IgG2a抗曼氏血吸虫单克隆抗体的体外和体内效应功能
J Immunol. 1982 Dec;129(6):2739-43.
2
Immunity after treatment of human schistosomiasis mansoni. I. Study design, pretreatment observations and the results of treatment.人类曼氏血吸虫病治疗后的免疫。I. 研究设计、治疗前观察及治疗结果
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3
The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms.用曼氏血吸虫尾蚴感染实验宿主并回收成虫。
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The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro.免疫恒河猴血清对曼氏血吸虫童虫体外培养的影响。
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Immunity after treatment of human schistosomiasis mansoni. II. Identification of resistant individuals, and analysis of their immune responses.
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Isotypic restriction of the antibody response to human immunodeficiency virus.针对人类免疫缺陷病毒的抗体反应的同型限制
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Absence of cross-reactivity between Schistosoma mansoni infection and human immunodeficiency virus (HIV).曼氏血吸虫感染与人类免疫缺陷病毒（HIV）之间不存在交叉反应。
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HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product.HIV F/3' 开放阅读框编码一种磷酸化的GTP结合蛋白，类似于一种癌基因产物。
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Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.具有sor基因缺失的HTLV-III/LAV的复制及致细胞病变潜力
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Regional variation in prevalence of antibody against human T-lymphotropic virus types I and III in Kenya, East Africa.东非肯尼亚地区抗I型和III型人类嗜T淋巴细胞病毒抗体流行率的区域差异。
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1型人类免疫缺陷病毒病毒体感染因子与曼氏血吸虫170-kD表面抗原之间的免疫交叉反应性。

Immunological crossreactivity between the human immunodeficiency virus type 1 virion infectivity factor and a 170-kD surface antigen of Schistosoma mansoni.

作者信息

Khalife J, Grzych J M, Pierce R, Ameisen J C, Schacht A M, Gras-Masse H, Tartar A, Lecocq J P, Capron A

机构信息

Centre d'Immunologie et de Biologie Parasitaire, Unité Mixte INSERM, U167-CNRS 624, Strasbourg, France.

出版信息

J Exp Med. 1990 Sep 1;172(3):1001-4. doi: 10.1084/jem.172.3.1001.

DOI:10.1084/jem.172.3.1001
PMID:1696953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188553/
Abstract

A monoclonal antibody (mAb) directed against a synthetic peptide derived from the sequence of the human immunodeficiency virus type 1 (HIV-1) regulatory protein virion infectivity factor (vif) labeled the surface of Schistosoma mansoni schistosomula by indirect immunofluorescence. Western blotting showed that two S. mansoni proteins of 170 and 65 kD were recognized by the mAb. Sera from 20% of S. mansoni-infected HIV-seronegative individuals tested recognized the PS4 peptide in an ELISA as did sera from S. mansoni-infected rats. Sera from individuals seropositive for HIV-1, but without schistosomiasis, that reacted with the vif peptide also recognized a 170-kD S. mansoni protein. This crossreactive S. mansoni antigen appears to be a target of immunity in vivo since passive transfer of the mAb VIF-CD3 to naive rats had a protective effect against a challenge infection with S. mansoni cercariae.

摘要

一种针对源自人类免疫缺陷病毒1型（HIV-1）调节蛋白病毒体感染因子（vif）序列的合成肽的单克隆抗体（mAb），通过间接免疫荧光标记了曼氏血吸虫童虫的表面。蛋白质印迹法显示，该单克隆抗体识别出曼氏血吸虫的两种蛋白质，分子量分别为170 kD和65 kD。在酶联免疫吸附测定（ELISA）中，20%受曼氏血吸虫感染且HIV血清学检测呈阴性的个体的血清，以及受曼氏血吸虫感染的大鼠的血清，均能识别PS4肽。HIV-1血清学检测呈阳性但无血吸虫病的个体的血清，与vif肽发生反应，也识别出一种170-kD的曼氏血吸虫蛋白。这种交叉反应性的曼氏血吸虫抗原似乎是体内免疫的一个靶点，因为将单克隆抗体VIF-CD3被动转移至未感染的大鼠，对曼氏血吸虫尾蚴攻击感染具有保护作用。