Rincon Fred, Mayer Stephan A
Neurological Intensive Care Unit, Division of Stroke and Critical Care, Department of Neurology, Columbia University, New York, New York, USA.
Semin Neurol. 2006 Sep;26(4):387-95. doi: 10.1055/s-2006-948319.
Morbidity and mortality in patients successfully resuscitated from cardiac arrest primarily depends on neurological outcome. Clinical trials of therapies directed toward reducing the extent of neuronal damage by means of pharmacological agents have been disappointing. To date, the only clinically effective tool for amelioration of brain damage by ischemia and reperfusion is mild to moderate induced hypothermia. The pathophysiology of global hypoxic-ischemic brain injury, the mechanisms by which hypothermia confers neuroprotection, and the encouraging beneficial effects of mild to moderate hypothermia in experimental studies and clinical trials are discussed.
心脏骤停后成功复苏患者的发病率和死亡率主要取决于神经学转归。旨在通过药物制剂减少神经元损伤程度的治疗方法的临床试验令人失望。迄今为止，减轻缺血再灌注脑损伤的唯一临床有效工具是轻度至中度诱导低温。本文讨论了全脑缺氧缺血性脑损伤的病理生理学、低温发挥神经保护作用的机制，以及轻度至中度低温在实验研究和临床试验中令人鼓舞的有益效果。
