Guo Hangyuan, Shen Jianyao, Lee Jong-Dae
Department of Cardiology, Shaoxing People's Hospital, First Affiliated Hospital of Medical College, Shaoxing University, Shaoxing, Zhejiang, China.
Acta Cardiol. 2006 Aug;61(4):475-9. doi: 10.2143/AC.61.4.2017311.
We describe two cases of Duchenne's cardiomyopathy with severe cardiac dysfunction, sporadic episodes of myoglobinuria induced by effort and increased levels of serum creatine kinase. Very mild signs of skeletal myopathy were clinically evident. Left ventriculography showed diffuse severe hypokinesia. Skeletal muscle biopsy demonstrated a dystrophic process. The patients had no familial background of the disease. These 2 patients might have a sporadic inheritance pattern with severe cardiac involvement.
我们描述了两例杜兴氏心肌病患者，他们伴有严重的心功能不全、运动诱发的散发性肌红蛋白尿发作以及血清肌酸激酶水平升高。临床上明显可见非常轻微的骨骼肌病体征。左心室造影显示弥漫性严重运动减弱。骨骼肌活检显示有营养不良过程。这些患者无该病的家族背景。这两名患者可能具有伴严重心脏受累的散发性遗传模式。
