Pervaiz Mohammad Hassan, Dickinson Michael G, Yamani Mohamad
Department of Medicine, Michigan State University, East Lansing 44824, USA.
Cleve Clin J Med. 2006 Sep;73(9):821-4, 826, 829-32 passim. doi: 10.3949/ccjm.73.9.821.
Digoxin has been the cornerstone of the treatment of heart failure for more than 2 centuries. Now that newer therapies have been introduced that reduce the mortality rate in heart failure and recent trials have failed to prove the same for digoxin, its use has significantly decreased. But a careful review of the multiple pharmacologic actions of digoxin and closer analysis of the results of recent trials suggest that digoxin may in fact continue to be an effective treatment for heart failure.
两个多世纪以来，地高辛一直是治疗心力衰竭的基石。鉴于已引入了能降低心力衰竭死亡率的新疗法，且近期试验未能证明地高辛有同样效果，其使用已大幅减少。但仔细审视地高辛的多种药理作用并深入分析近期试验结果表明，地高辛实际上可能仍是治疗心力衰竭的有效药物。
