[癌症化疗中抗肿瘤免疫力的增强]
[Augmentation of antitumor immunity in cancer chemotherapy].
作者信息
Hosokawa M, Kobayashi H
机构信息
Cancer Institute, Hokkaido University School of Medicine.
出版信息
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1402-6.
Cancer chemotherapeutic drugs (antitumor drugs) generally inhibit host immune responses to cancer cells. Some antitumor drugs, however, can augment antitumor immune responses if they were administered appropriately. The immuno-augmentation brought about by antitumor drugs might concrete the effects of cancer chemotherapy. The authors introduced their experiments in which they have observed a typical BRM-like effects of bleomycin on tumor-bearing rats and discussed the significance of immuno-augmenting effects of antitumor drugs in cancer chemotherapy.
癌症化疗药物（抗肿瘤药物）通常会抑制宿主对癌细胞的免疫反应。然而，一些抗肿瘤药物如果使用得当，也可以增强抗肿瘤免疫反应。抗肿瘤药物带来的免疫增强作用可能会巩固癌症化疗的效果。作者介绍了他们的实验，在实验中他们观察到博来霉素对荷瘤大鼠具有典型的生物反应调节剂样作用，并讨论了抗肿瘤药物免疫增强作用在癌症化疗中的意义。
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