Nathens Avery B, Rivara Frederick P, Mack Christopher D, Rubenfeld Gordon D, Wang Jin, Jurkovich Gregory J, Maier Ronald V
Harborview Injury Prevention and Research Center, Seattle, WA, USA.
Crit Care Med. 2006 Dec;34(12):2919-24. doi: 10.1097/01.CCM.0000243800.28251.AE.
The utility of tracheostomy to expedite weaning and prevent complications in patients with acute respiratory failure is actively debated, with many physicians holding strong opinions regarding the value and timing of this intervention. We postulated that these opinions would be reflected in significant variation in tracheostomy rates across centers. Thus, we set out explore the extent and potential sources of this variation among injured patients cared for in trauma centers in the United States.
This is a retrospective cohort study. We used stratification and hierarchical multivariate analysis to evaluate the effect of patient and institutional characteristics on tracheostomy rates and variance decomposition to determine the proportion of variance across institutions explained by patient characteristics.
Intensive care units within trauma centers participating in the National Trauma Databank.
Injured patients admitted over the years 2001-2003, age >/=16 yrs, with an Injury Severity Score >/=9 and a diagnosis of acute respiratory failure, excluding patients with burn injuries and those with a severe injury to the face or neck who might require tracheostomy for maintenance of an airway.
None.
There were 17,523 patients meeting inclusion criteria: 4,146 (24%) underwent tracheostomy. The mean tracheostomy rate across centers was 19.6 per 100 hospital admissions with a range of 0-59. This variation persisted after stratification by age, injury mechanism, and severity. Although several patient and injury characteristics were predictive of tracheostomy, there were no identifiable institutional characteristics associated with tracheostomy. Patient characteristics accounted for only 14% of the variance across centers.
There is significant unexplained variation in the rates of tracheostomy in critically injured patients with acute respiratory failure. This variation might reflect preconceived notions of efficacy among physicians practicing in the absence of evidence to guide care. The variation provides evidence of equipoise and emphasizes the need for a well-conducted randomized controlled trial to evaluate the utility of this procedure.
气管切开术在急性呼吸衰竭患者中对于加速撤机和预防并发症的作用存在着激烈的争论,许多医生对该干预措施的价值和时机持有坚定的观点。我们推测这些观点会反映在各中心气管切开率的显著差异上。因此,我们着手探究美国创伤中心收治的受伤患者中这种差异的程度及潜在来源。
这是一项回顾性队列研究。我们采用分层和分层多变量分析来评估患者和机构特征对气管切开率的影响,并进行方差分解以确定患者特征在各机构间差异中所占的比例。
参与国家创伤数据库的创伤中心内的重症监护病房。
2001年至2003年收治的年龄≥16岁、损伤严重度评分≥9且诊断为急性呼吸衰竭的受伤患者,不包括烧伤患者以及面部或颈部严重受伤可能需要气管切开以维持气道的患者。
无。
有17523例患者符合纳入标准,其中4146例(24%)接受了气管切开术。各中心的平均气管切开率为每100例住院患者19.6例,范围为0至59例。按年龄、损伤机制和严重程度分层后,这种差异依然存在。尽管一些患者和损伤特征可预测气管切开术,但未发现与气管切开术相关的可识别的机构特征。患者特征仅占各中心间差异的14%。
在患有急性呼吸衰竭的重症受伤患者中,气管切开率存在显著的无法解释的差异。这种差异可能反映了在缺乏证据指导治疗的情况下,医生们对疗效的先入之见。这种差异提供了 equipoise 的证据,并强调需要进行一项精心设计的随机对照试验来评估该手术的效用。