Hazenberg Jan G, Taylor David, Lee T Clive
Department of Anatomy, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland.
Osteoporos Int. 2007 Jan;18(1):1-8. doi: 10.1007/s00198-006-0222-y. Epub 2006 Sep 14.
The skeleton alters its geometry following trauma, the introduction of artificial defects and of fatigue-induced microcracks. The precise mechanism by which the skeleton adapts remains unclear. Microcracks might directly affect the cell by damaging the osteocyte cell network or causing apoptosis. Bone microstructure may play an important role in these processes by diverting and arresting propagating microcracks and so prevent fracture failure. This paper discusses the effects of microstructure on propagating cracks, how microdamage may act as a stimulus for bone adaptation and its potential effects on bone biochemistry.
骨骼在遭受创伤、出现人为缺损以及疲劳诱导产生微裂纹后会改变其几何形状。骨骼适应的精确机制尚不清楚。微裂纹可能通过破坏骨细胞网络或导致细胞凋亡直接影响细胞。骨微结构可能在这些过程中发挥重要作用，通过转移和阻止微裂纹扩展从而防止骨折。本文讨论了微结构对扩展裂纹的影响、微损伤如何作为骨适应的刺激因素以及其对骨生物化学的潜在影响。
