Harrison S C, Ferguson D R, Hanley M R
Department of Urology, Addenbrooke's Hospital, Cambridge.
Br J Urol. 1990 Aug;66(2):155-61. doi: 10.1111/j.1464-410x.1990.tb14894.x.
The sensory innervation of the rabbit urinary bladder was studied using local application of the specific sensory neurotoxin capsaicin (8-methyl-N-vanillyl-6-nonenamide). This agent has its major effect by damaging small diameter unmyelinated sensory nerves. The drug produced a 51% reduction in the bladder content of the neuropeptide substance P. It therefore appears that a substantial proportion of the bladder's content of the peptide is to be found in capsaicin-sensitive sensory nerves. Cystometrograms carried out before and after treatment with capsaicin were similar; this suggests that capsaicin-sensitive sensory nerves may not be of importance in the afferent limb of the micturition reflex. In vitro muscle strip studies demonstrated a small reduction in the sensitivity of the detrusor muscle to electrical stimulation of its intramural nerves. It is possible that in vitro intramural nerve stimulation leads to release of neurotransmitters from sensory as well as motor nerves. It is proposed that small diameter sensory nerves in the bladder wall may have a role in the transmission of the sensation of pain and in the triggering of inflammatory reactions rather than forming the afferent limb of the micturition reflex.
采用局部应用特异性感觉神经毒素辣椒素（8-甲基-N-香草基-6-壬酰胺）的方法，对家兔膀胱的感觉神经支配进行了研究。该药物的主要作用是损伤小直径无髓感觉神经。药物使神经肽P物质在膀胱中的含量降低了51%。因此，似乎该肽在膀胱中的相当一部分含量存在于对辣椒素敏感的感觉神经中。在用辣椒素治疗前后进行的膀胱压力容积测定结果相似；这表明对辣椒素敏感的感觉神经在排尿反射的传入支中可能并不重要。体外肌条研究表明，逼尿肌对其壁内神经电刺激的敏感性略有降低。体外壁内神经刺激可能导致感觉神经和运动神经释放神经递质。有人提出，膀胱壁中的小直径感觉神经可能在疼痛感觉的传递和炎症反应的触发中起作用，而不是形成排尿反射的传入支。
