Schempp Christoph M, Simon-Haarhaus Birgit, Krieger Richard, Simon Jan C
Department of Dermatology, University Medical Center, Freiburg, Germany.
Planta Med. 2006 Aug;72(10):941-3. doi: 10.1055/s-2006-947166.
Dictamnine, a furoquinoline alkaloid of the Rutaceae plant family, has been shown to be mutagenic and phototoxic in bacteria and yeasts. Here, we have investigated the phototoxic effect of dictamnine in human Jurkat T cells and HaCaT keratinocytes. Dictamnine was isolated from the roots of DICTAMNUS ALBA L. and was photoactivated with solar simulated radiation, delivered from a 1000-W xenon arc lamp with a maximal output between 300 - 800 nm. Dictamnine displayed concentration- and light-dependent phototoxic effects in both cell lines. In comparison to the structurally related furocoumarins 5-methoxypsoralen and 8-methoxypsoralen, dictamnine was less phototoxic. Nevertheless, it may play a major role in the elicitation of phytophotodermatitis because of its abundance in plants of the Rutaceae family.
白鲜碱是芸香科植物中的一种呋喃喹啉生物碱，已被证明在细菌和酵母中具有致突变性和光毒性。在此，我们研究了白鲜碱对人 Jurkat T 细胞和 HaCaT 角质形成细胞的光毒性作用。白鲜碱从白鲜根中分离得到，并用 1000 瓦氙弧灯模拟太阳辐射进行光活化，其最大输出波长在 300 - 800 纳米之间。白鲜碱在两种细胞系中均表现出浓度和光依赖性光毒性作用。与结构相关的呋喃香豆素 5-甲氧基补骨脂素和 8-甲氧基补骨脂素相比，白鲜碱的光毒性较小。然而，由于其在芸香科植物中含量丰富，它可能在植物性光皮炎的诱发中起主要作用。
