Popović Ljiljana, Zamaklar Miroslava, Lalić Katarina, Vasović Olga
Srp Arh Celok Lek. 2006 May-Jun;134(5-6):219-23. doi: 10.2298/sarh0606219p.
Diabetes type 2 is a chronic metabolic disorder. Pathogenesis of diabetes type 2 results from the impaired insulin secretion, impaired insulin action and increased endogenous glucose production. Diabetes evolves through several phases characterized by qualitative and quantitative changes of beta cell secretory function. The aim of our study was to analyze the impact of diabetes duration on beta cell secretory function and insulin resistance. The results indicated significant negative correlation of diabetes duration and fasting insulinemia, as well as beta cell secretory function assessed by HOMA beta index. Our study also found significant negative correlation of diabetes duration and insulin resistance assessed by HOMA IR index. Significant positive correlation was established between beta cell secretory capacity (fasting insulinemia and HOMA beta) and insulin resistance assessed by HOMA IR index, independently of diabetes duration. These results indicate that: beta cell secretory capacity, assessed by HOMA beta index, significantly decreases with diabetes duration. In parallel with decrease of fasting insulinemia, reduction of insulin resistance assessed by HOMA IR index was found as well.
2型糖尿病是一种慢性代谢紊乱疾病。2型糖尿病的发病机制源于胰岛素分泌受损、胰岛素作用受损以及内源性葡萄糖生成增加。糖尿病通过几个阶段发展，其特征是β细胞分泌功能的质和量的变化。我们研究的目的是分析糖尿病病程对β细胞分泌功能和胰岛素抵抗的影响。结果表明，糖尿病病程与空腹胰岛素血症以及通过HOMA-β指数评估的β细胞分泌功能呈显著负相关。我们的研究还发现，糖尿病病程与通过HOMA-IR指数评估的胰岛素抵抗呈显著负相关。在不考虑糖尿病病程的情况下，通过HOMA-IR指数评估的胰岛素抵抗与β细胞分泌能力（空腹胰岛素血症和HOMA-β）之间建立了显著正相关。这些结果表明：通过HOMA-β指数评估的β细胞分泌能力随着糖尿病病程显著降低。与空腹胰岛素血症的降低同时，还发现通过HOMA-IR指数评估的胰岛素抵抗也有所降低。
