[类风湿关节炎相关骨病]
[Bone disease related to rheumatoid arthritis].
作者信息
Tanaka Sakae
机构信息
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo.
出版信息
Nihon Rinsho. 2006 Sep;64(9):1712-7.
PMID:16972685
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone destruction, in which proinflammatory cytokines such as tumor necrosis factor-alpha play essential roles. Recent studies have revealed an important involvement of osteoclasts in bone destruction of RA. In this review, I would like to explain the molecular mechanism of osteoclast development in RA, and propose the possibility of anti-osteoclast therapy to the disease.
摘要
类风湿性关节炎（RA）是一种以进行性骨质破坏为特征的慢性炎症性疾病，其中肿瘤坏死因子-α等促炎细胞因子起着关键作用。最近的研究表明破骨细胞在类风湿性关节炎的骨质破坏中起重要作用。在这篇综述中，我将解释类风湿性关节炎中破骨细胞发育的分子机制，并提出针对该疾病进行抗破骨细胞治疗的可能性。
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