打开适应性工具箱。

Opening the adaptive toolbox.

作者信息

Wittes Janet, Lachenbruch Peter A

机构信息

Statistics Collaborative, 1625 Massachusetts Ave., NW, Washington, DC 20036, USA.

出版信息

Biom J. 2006 Aug;48(4):598-603; discussion 613-22. doi: 10.1002/bimj.200610240.

DOI:10.1002/bimj.200610240

PMID:16972711

Abstract

This is a discussion of the following three papers appearing in this special issue on adaptive designs: 'A regulatory view on adaptive/flexible clinical trial design' by H. M. James Hung, Robert T. O'Neill, Sue-Jane Wang and John Lawrence; 'Confirmatory clinical trials with an adaptive design' by Armin Koch; and 'FDA's critical path initiative: A perspective on contributions of biostatistics' by Robert T. O'Neill.

摘要