Reid Susan M, Lanigan Anna, Reddihough Dinah S
Murdoch Childrens Research Institute, Department of Child Development and Rehabilitaion, Royal Children's Hospital, Victoria, Australia.
J Paediatr Child Health. 2006 Oct;42(10):606-11. doi: 10.1111/j.1440-1754.2006.00936.x.
To use the information from a population-based cerebral palsy register to describe post-neonatally acquired cerebral palsy, to determine trends over time and relate any aetiological trends to community preventative measures.
Data on cases of post-neonatally acquired cerebral palsy, between the birth years 1970 and 1999, were generated from the Victorian Cerebral Palsy Register. Distributions, rates and trends over time were calculated for the entire cohort and for subgroups according to gender, age at acquisition, aetiology, gestation at delivery, birthweight, maternal age at delivery and parity.
339 cases were found with post-neonatally acquired cerebral palsy, accounting for 10.7% of all cerebral palsy and giving an overall rate of 1.98/10 000 live births. There was a statistically significant fall in the overall rate of post-neonatally acquired cerebral palsy (P = 0.001) over the study period. Significant falls were seen in post-neonatal cerebral palsy due to infection, traumatic head injury and hypoxia and other acute encephalopathies, but not cerebrovascular accidents.
A large proportion of post-neonatally acquired cerebral palsy is preventable. While the reported decline in cases in Victoria is encouraging, it will be important to monitor these trends over time, and continue public health measures to further reduce preventable causes.
利用基于人群的脑瘫登记册中的信息来描述新生儿期后获得性脑瘫,确定其随时间的变化趋势,并将任何病因学趋势与社区预防措施相关联。
1970年至1999年出生年份间新生儿期后获得性脑瘫病例的数据来自维多利亚州脑瘫登记册。计算了整个队列以及按性别、获得脑瘫时的年龄、病因、分娩时的孕周、出生体重、母亲分娩时年龄和产次划分的亚组的分布、发生率和随时间的变化趋势。
发现339例新生儿期后获得性脑瘫病例,占所有脑瘫病例的10.7%,总体发生率为1.98/10000活产。在研究期间,新生儿期后获得性脑瘫的总体发生率有统计学意义的下降(P = 0.001)。因感染、创伤性脑损伤、缺氧及其他急性脑病导致的新生儿期后脑瘫有显著下降,但脑血管意外导致的没有。
很大一部分新生儿期后获得性脑瘫是可预防的。虽然维多利亚州报告的病例下降令人鼓舞,但随着时间的推移监测这些趋势并继续采取公共卫生措施以进一步减少可预防的病因将很重要。