Gloria-Bottini F, Meloni G F, Grassi S, Bottini N, Saccucci P, Giarrizzo G F, Magrini A, Bergamaschi A, Bottini E
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Rome, Italy.
Early Hum Dev. 2007 Jun;83(6):349-54. doi: 10.1016/j.earlhumdev.2006.07.005. Epub 2006 Sep 14.
Data from previous study by our group suggest that in smoking women sex ratio of offspring is higher in newborns carrying ACP1C allele than in other ACP1 genotypes, suggesting that differences observed among human population concerning the effect of smoking may depend in part on this genetic factor.
In order to further explore this issue we have studied another population and have analysed the relationship between sex ratio and ACP1C gene frequency at population level.
The analysis includes 719 consecutive births from Central Italy considered in a previous paper and 5510 consecutive births from Sardinia. Data from English and Japanese populations have also been considered in the analysis.
Among newborns not carrying ACP1C there is a decrease of SR among the offspring of smoking mothers, while among newborns carrying the ACP1C allele there is an increase of SR among the offspring of smoking mothers relative to non-smoking mothers. Considering Sardinian, Italian, English and Japanese population there is a linear positive relationship between C allele frequency and SR in smoking mothers.
The present observation suggests an interaction between smoking and ACP1 regarding their effects on sex ratio, by which the presence of the ACP1C allele appears to counteract the effect of smoking. This suggests that genetic background may modify the effects of toxic environmental factors on gamete production and functionality and/or on intrauterine survival.
我们团队之前的研究数据表明，在吸烟女性中，携带 ACP1C 等位基因的新生儿的后代性别比高于其他 ACP1 基因型的新生儿，这表明在人群中观察到的吸烟影响方面的差异可能部分取决于这个遗传因素。
为了进一步探讨这个问题，我们研究了另一人群，并在人群水平上分析了性别比与 ACP1C 基因频率之间的关系。
分析包括先前一篇论文中考虑的来自意大利中部的 719 例连续出生病例以及来自撒丁岛的 5510 例连续出生病例。分析中还考虑了来自英国和日本人群的数据。
在不携带 ACP1C 的新生儿中，吸烟母亲的后代性别比下降，而在携带 ACP1C 等位基因的新生儿中，吸烟母亲的后代性别比相对于不吸烟母亲有所增加。考虑撒丁岛、意大利、英国和日本人群，吸烟母亲中 C 等位基因频率与性别比之间存在线性正相关。
目前的观察结果表明吸烟与 ACP1 在对性别比的影响方面存在相互作用，其中 ACP1C 等位基因的存在似乎抵消了吸烟的影响。这表明遗传背景可能会改变有毒环境因素对配子产生和功能及/或子宫内生存的影响。
