谷胱甘肽S转移酶M1和T1基因多态性与原发性开角型青光眼的风险相关：一项土耳其人群研究。
Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population.
作者信息
Unal Mustafa, Güven Mehmet, Devranoğlu Kazim, Ozaydin Ahmet, Batar Bahadir, Tamçelik Nevbahar, Görgün Ebru Eroğlu, Uçar Didar, Sarici Ahmet
机构信息
Department of Ophthalmology, Akdeniz University Medical Faculty, Antalya, Turkey.
出版信息
Br J Ophthalmol. 2007 Apr;91(4):527-30. doi: 10.1136/bjo.2006.102418. Epub 2006 Sep 14.
BACKGROUND
Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).
AIM
To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.
METHODS
Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.
RESULTS
The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).
CONCLUSION
The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.
背景
遗传因素和氧化损伤已被证明在原发性开角型青光眼（POAG）的发病过程中起作用。
目的
确定谷胱甘肽S转移酶（GST）M1和GSTT1基因多态性对土耳其人群POAG发病风险的影响。
方法
采用多重聚合酶链反应（PCR），对144例POAG患者和121例年龄相仿的健康对照者进行GSTM1和GSTT1基因多态性分析。
结果
GSTM1阳性基因型和GSTT1缺失基因型患POAG的风险增加（p<0.001，OR分别为2.93，95%CI为1.66至5.20；OR为4.25，95%CI为2.30至7.80）。GSTM1阳性和GSTT1缺失基因型同时存在的受试者患青光眼的风险也显著增加（p<0.001，OR为3.46，95%CI为1.64至7.38）。
结论
GSTM1阳性基因型和GSTT1缺失基因型或两者的组合可能与土耳其人群POAG发病风险增加有关。
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