Boroń-Kaczmarska A, Boroń P, Puch U, Hryniewicz A, Bobrowska E
Institut für Klinische Physiologie, Klinik für Infektionskrankheiten, Medizinischen Akademie Białystok.
Z Gesamte Inn Med. 1990 May 15;45(10):294-6.
Immunomodulating effect of isoprinosine was estimated in group of 10 patients with postalcoholic liver cirrhosis and compared with another group of 10 patients with postinflammatory liver cirrhosis with infection of hepatitis B virus. Disturbances of immunologic reactivity in the patients with postalcoholic liver cirrhosis mainly concerned increased immunoglobulin G, A concentrations in the blood serum, decreased percentage values of lymphocytes T and their subpopulations (lymphocytes T4 and T8) and increased percentage of lymphocytes B. Disturbances of the examined indices of the immunologic reactivity in the group of patient with postinflammatory liver cirrhosis concerned increased concentrations of circulating immunologic complexes, immunoglobulins A and M in the blood serum and decreased percentage of lymphocytes T and their subpopulation. Treatment with isoprinosine resulted in different immunologic effect in the examined patients concerning mainly increased concentrations of circulating immunologic complexes in the blood serum and increased percentage values of lymphocytes T, T4, T8, B in the course of postalcoholic liver cirrhosis. Patients with postinflammatory liver cirrhosis treated with isoprinosine mainly showed decreased concentrations of circulating immunologic complexes, immunoglobulins A, M the blood serum, increased percentage values of lymphocytes T4 and T8.
对10例酒精性肝硬化患者组成的一组人群评估了异丙肌苷的免疫调节作用，并与另一组10例感染乙型肝炎病毒的炎症后肝硬化患者进行了比较。酒精性肝硬化患者免疫反应性紊乱主要涉及血清中免疫球蛋白G、A浓度升高，淋巴细胞T及其亚群（淋巴细胞T4和T8）的百分比值降低，以及淋巴细胞B百分比升高。炎症后肝硬化患者组免疫反应性检查指标的紊乱涉及循环免疫复合物、血清中免疫球蛋白A和M浓度升高，以及淋巴细胞T及其亚群百分比降低。异丙肌苷治疗使受检患者产生了不同的免疫效应，在酒精性肝硬化过程中主要表现为血清中循环免疫复合物浓度升高以及淋巴细胞T、T4、T8、B百分比值升高。接受异丙肌苷治疗的炎症后肝硬化患者主要表现为血清中循环免疫复合物、免疫球蛋白A、M浓度降低，淋巴细胞T4和T8百分比值升高。
