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人类胰岛素样生长因子（IGF）结合蛋白的调节。在健康成年人和胰腺外肿瘤性低血糖患者接受IGF I治疗期间，IGF结合蛋白2表达增加。

Regulation of binding proteins for insulin-like growth factors (IGF) in humans. Increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia.

作者信息

Zapf J, Schmid C, Guler H P, Waldvogel M, Hauri C, Futo E, Hossenlopp P, Binoux M, Froesch E R

机构信息

Department of Medicine, University Hospital of Zürich, Switzerland.

出版信息

J Clin Invest. 1990 Sep;86(3):952-61. doi: 10.1172/JCI114797.

DOI:10.1172/JCI114797
PMID:1697608
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC296815/
Abstract

UNLABELLED

Insulin-like growth factors (IGFs) in blood form two complexes with specific binding proteins (BPs): a large, growth hormone (GH)-dependent complex with restricted capillary permeability, and a smaller complex, inversely related to GH, with high turnover of its IGF pool and free capillary permeability. The distribution of BPs and of IGFs I and II between these complexes was studied in sera from healthy adults treated with IGF I or/and GH and from patients with extrapancreatic tumor hypoglycemia. Like GH, IGF I administration raises IGF I and two glycosylation variants of IGFBP-3 in the large complex, but unlike GH drastically reduces IGF II. During IGF I infusion, IGFBP-3 appears in the small complex whose IGFBP-2 and IGF I increase three- to fivefold and fivefold, respectively. GH treatment, associated with elevated insulin levels, suppresses IGFBP-2 and inhibits its increase owing to infused IGF I. The small complex of tumor sera contains increased amounts of IGFBP-2 and -3, and two- to threefold elevated IGF II.

CONCLUSIONS

low GH and/or insulin during IGF I infusion and in extrapancreatic tumor hypoglycemia enhance expression of IGFBP-2 and favor partition of IGFBP-3 into the small complex. Free capillary passage and high turnover of its increased IGF I or II pools may contribute to compensate for suppressed insulin secretion during IGF I infusion or to development of tumor hypoglycemia.

摘要

未标记

血液中的胰岛素样生长因子（IGFs）与特定结合蛋白（BPs）形成两种复合物：一种是与生长激素（GH）相关的大复合物，具有受限的毛细血管通透性；另一种是较小的复合物，与GH呈负相关，其IGF库周转率高且毛细血管通透性高。在接受IGF I或/和GH治疗的健康成年人以及患有胰腺外肿瘤性低血糖症患者的血清中，研究了这些复合物之间BP以及IGF I和II的分布情况。与GH一样，给予IGF I会使大复合物中的IGF I和IGFBP - 3的两种糖基化变体增加，但与GH不同的是，它会大幅降低IGF II。在输注IGF I期间，IGFBP - 3出现在小复合物中，其IGFBP - 2和IGF I分别增加三至五倍和五倍。GH治疗与胰岛素水平升高相关，会抑制IGFBP - 2并抑制其因输注IGF I而增加。肿瘤血清的小复合物中IGFBP - 2和 - 3的含量增加，IGF II升高两至三倍。

结论

在输注IGF I期间以及胰腺外肿瘤性低血糖症中，低GH和/或胰岛素会增强IGFBP - 2的表达，并有利于IGFBP - 3分配到小复合物中。其增加的IGF I或II库的自由毛细血管通过和高周转率可能有助于补偿输注IGF I期间胰岛素分泌的抑制或肿瘤性低血糖症的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/db52b70db133/jcinvest00075-0284-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/db52b70db133/jcinvest00075-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/dc98ccc2a077/jcinvest00075-0279-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/93c2b717ba7c/jcinvest00075-0280-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/03c234372ea1/jcinvest00075-0280-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/56347e694d7b/jcinvest00075-0281-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/ffd6bb68e809/jcinvest00075-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/18b0593cc5c0/jcinvest00075-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/e7ed4ed7903d/jcinvest00075-0283-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1266/296815/db52b70db133/jcinvest00075-0284-a.jpg

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