Noda Takehiro, Higashiyama Masahiko, Oda Kazuyuki, Higaki Naozumi, Takami Koji, Okami Jiro, Kodama Ken, Kuriyama Keiko, Tsukamoto Yoshitane, Kobayashi Hisayuki
Departments of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Ann Thorac Cardiovasc Surg. 2006 Aug;12(4):273-8.
A case report of mucoepidermoid carcinoma of the thymus, aggressively treated by multimodality therapy including surgery, radiotherapy, chemothermotherapy, and systemic chemotherapy is presented. The patient, a 53-year-old man, underwent potentially complete resection for an anterior mediastinal tumor, histologically diagnosed as a mucoepidermoid carcinoma of the thymus with Masaoka stage II disease. However, because of local recurrences in the left chest wall and pleura, re-resection was twice performed 4 years and 5 months, and 5 years and 7 months after the initial surgery, in combination with intrathoracic chemothermotherapy and irradiation. Seven years and 1 month after the initial operation, in vitro chemosensitive test based-chemotherapy using vinorelbine for pleural disease was performed, resulting in maintenance of good quality of life (QOL) due to dramatic decrease in pleural effusion. He died of tumor progression, 7 years and 9 months after the initial treatment. Although the clinical aspects of thymic mucoepidermoid carcinoma are little known, it is assumed that such aggressive therapeutic multimodalities as repeated surgical resection, irradiation and chemothermotherapy, and chemotherapy based on in vitro chemosensitivity tests contributed to long-term survival for this unusual disease.
本文报告了一例胸腺黏液表皮样癌病例，采用包括手术、放疗、热化疗和全身化疗在内的多模式疗法积极治疗。患者为一名53岁男性，因前纵隔肿瘤接受了可能的完整切除，组织学诊断为Masaoka II期胸腺黏液表皮样癌。然而，由于左胸壁和胸膜局部复发，分别在初次手术后4年5个月和5年7个月进行了两次再次切除，并结合胸腔内化疗和放疗。初次手术后7年1个月，对胸膜疾病采用基于体外化疗敏感性试验的长春瑞滨化疗，由于胸腔积液显著减少，患者生活质量得以维持。患者在初次治疗后7年9个月死于肿瘤进展。尽管胸腺黏液表皮样癌的临床情况鲜为人知，但据推测，重复手术切除、放疗和化疗以及基于体外化疗敏感性试验的化疗等积极的多模式治疗有助于这种罕见疾病的长期生存。
