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本文引用的文献

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The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis.在植物微小RNA生物合成过程中，DCL1与HYL1之间的相互作用对于前体微小RNA（pri-miRNA）的高效精确加工至关重要。
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SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis.锯齿状基因（SERRATE）协调拟南芥茎尖分生组织功能和叶片轴向模式形成。
Nature. 2005 Oct 13;437(7061):1022-6. doi: 10.1038/nature04052.
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Auxin response factors mediate Arabidopsis organ asymmetry via modulation of KANADI activity.生长素响应因子通过调节KANADI活性介导拟南芥器官不对称性。
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microRNA172 down-regulates glossy15 to promote vegetative phase change in maize.微小RNA172通过下调光泽15来促进玉米营养生长阶段的转变。
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microRNA-directed phasing during trans-acting siRNA biogenesis in plants.植物中转录后基因沉默小干扰RNA生物合成过程中的微小RNA定向相位调控
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MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for arabidopsis lateral root development.微小RNA引导转录因子NAC1的信使核糖核酸切割，以下调生长素信号，从而影响拟南芥侧根发育。
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Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana.拟南芥中Dicer样蛋白与HYL1/DRB家族双链RNA结合蛋白之间的特异性相互作用。
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10
microRNA-directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems.微小RNA介导的ATHB15信使核糖核酸切割调控拟南芥花序茎中的维管发育。
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锯齿状蛋白：植物微小RNA领域的新成员。

SERRATE: a new player on the plant microRNA scene.

作者信息

Lobbes Dajana, Rallapalli Ghanasyam, Schmidt Dominik D, Martin Cathie, Clarke Jonathan

机构信息

Department of Cell and Developmental Biology, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK.

出版信息

EMBO Rep. 2006 Oct;7(10):1052-8. doi: 10.1038/sj.embor.7400806. Epub 2006 Sep 15.

DOI:10.1038/sj.embor.7400806
PMID:16977334
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1618363/
Abstract

MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants defective in miRNA accumulation. Although it has been proposed that SERRATE (SE) functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA, microarray analysis shows upregulation of many genes known to be the targets of miRNAs in se-1. We show that SE is a general regulator of miRNA levels affecting the processing of primary miRNA to miRNA.

摘要

微小RNA（miRNA）作为序列特异性向导，通过转录后基因沉默来控制基因表达。许多miRNA通过调节编码转录因子的转录本积累来影响植物发育。在miRNA积累方面存在缺陷的突变体，如dcl1、hen1、hyl1和ago1，具有多效性发育表型。拟南芥的锯齿叶-1（se-1）突变体也表现出高度多效性表型，这与miRNA积累缺陷突变体的表型重叠。尽管有人提出锯齿叶（SE）在miRNA介导的对叶极性基因PHABULOSA和PHAVOLUTA的抑制中具有特异性功能，但微阵列分析显示，在se-1中许多已知为miRNA靶标的基因上调。我们表明，SE是miRNA水平的一般调节因子，影响初级miRNA加工成miRNA。