MacGillivray John D, Fealy Stephen, Terry Michael A, Koh Jason L, Nixon Alan J, Warren Russell F
Department of Sports Medicine & Shoulder Service, Hospital for Special Surgery, New York, NY, USA.
J Shoulder Elbow Surg. 2006 Sep-Oct;15(5):639-44. doi: 10.1016/j.jse.2005.11.009.
A bioresorbable patch used for augmentation of rotator cuff repair was evaluated to determine if it would increase strength of cuff repairs associated with tendon defects and also show histologic incorporation over time. Forty goats underwent rotator cuff repairs of the infraspinatus tendon bilaterally. Tendons were detached and a defect was created prior to repair. One side was repaired and augmented with a 4 cm2 polylactic acid patch in each animal. On the other side, the same size defect was repaired in the same manner but without the patch to serve as a control. Animals were sacrificed at 3, 6, 12, and 24 weeks. Ultimate load to failure and histology were reported. No significant difference in load to failure was found between groups. A cellular fibrous tissue occupied the patch at 6 weeks, which over time matured into a dense, homogeneous fibrous tissue with alignment of collagen between the scaffold bundles.
对一种用于增强肩袖修复的生物可吸收补片进行了评估，以确定其是否会增加与肌腱缺损相关的肩袖修复强度，并随着时间推移显示出组织学上的融合。40只山羊双侧进行冈下肌腱的肩袖修复。在修复前将肌腱切断并制造缺损。每只动物的一侧进行修复并用4平方厘米的聚乳酸补片增强。另一侧以相同方式修复相同大小的缺损，但不使用补片作为对照。在3周、6周、12周和24周时对动物实施安乐死。报告了最终破坏负荷和组织学情况。两组之间在破坏负荷方面未发现显著差异。6周时，一种细胞性纤维组织占据了补片，随着时间推移，其成熟为致密、均匀的纤维组织，支架束之间的胶原排列整齐。
