Yang Jinwei, Kang Yuhao, Zhao Wanlu, Jiang Jia, Jiang Yanbiao, Zhao Bing, Jiao Mingyue, Yuan Bo, Zhao Jinzhong, Ma Bin
Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China.
Reproductive Medicine Center, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, 730050, China.
Bioact Mater. 2021 Aug 28;10:474-491. doi: 10.1016/j.bioactmat.2021.08.016. eCollection 2022 Apr.
Based on the published animal studies, we systematically evaluated the outcomes of various materials for rotator cuff repair in animal models and the potentials of their clinical translation. 74 animal studies were finally included, of which naturally derived biomaterials were applied the most widely (50.0%), rats were the most commonly used animal model (47.0%), and autologous tissue demonstrated the best outcomes in all animal models. The biomechanical properties of naturally derived biomaterials (maximum failure load: WMD 18.68 [95%CI 7.71-29.66]; P = 0.001, and stiffness: WMD 1.30 [95%CI 0.01-2.60]; P = 0.048) was statistically significant in the rabbit model. The rabbit model showed better outcomes even though the injury was severer compared with the rat model.
基于已发表的动物研究，我们系统评估了动物模型中用于肩袖修复的各种材料的效果及其临床转化潜力。最终纳入了74项动物研究，其中天然衍生生物材料应用最为广泛（50.0%），大鼠是最常用的动物模型（47.0%），自体组织在所有动物模型中显示出最佳效果。在兔模型中，天然衍生生物材料的生物力学性能（最大破坏载荷：加权均数差18.68 [95%置信区间7.71 - 29.66]；P = 0.001，以及刚度：加权均数差1.30 [95%置信区间0.01 - 2.60]；P = 0.048）具有统计学意义。尽管与大鼠模型相比损伤更严重，但兔模型显示出更好的效果。
