Korkmaz Cengiz, Us Tercan, Kaşifoğlu Timuçin, Akgün Yurdanur
Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University Medical Faculty, 26480, Eskişehir, Türkiye.
Clin Biochem. 2006 Oct;39(10):961-5. doi: 10.1016/j.clinbiochem.2006.06.004. Epub 2006 Jul 13.
To evaluate frequency of anti-cyclic citrullinated peptide antibodies (anti-CCP) in long-standing rheumatoid arthritis (LsRA) patients and their relationship with extra-articular manifestations of rheumatoid arthritis (RA), in addition to comparing frequency of anti-CCP antibodies in early RA (ERA) and LsRA group.
One hundred and fifteen consecutive RA patients were included in the study as having LsRA because their disease duration was longer than 3 years. Thirty-nine consecutive patients with RA were included in the study as having ERA (<3 years). Also, 64 individuals were included in the study as healthy controls to verify the specificity and sensitivity of anti-CCP antibodies. Anti-CCP antibody and rheumatoid factor (RF) were evaluated with enzyme-linked immunosorbent assay kits and standard nephelometry methods, respectively. Extra-articular manifestations were diagnosed by relevant criteria.
The total number of patients with extra-articular manifestations was found to be 45 (39%). No significant difference was found between LsRA group and ERA group in terms of extra-articular manifestations. There were no differences between both groups regarding the number of patients with positive anti-CCP antibodies and the levels of anti-CCP antibodies. In LsRA group, there was a positive correlation between erosion and disease duration (r=0.24, p<0.01), between erosion and RF (r=0.29, p<0.002), and between erosion and anti-CCP antibody (r=0.21, p<0.02). Positive correlations between RF and anti-CCP antibody (r=0.32, p<0.0001), as well as between subcutaneous nodule and lung involvement (r=0.24, p<0.008), were found in the LsRA group. However, no positive correlation could be found between anti-CCP antibody positivity and extra-articular organ involvement, either cumulatively or separately.
Although anti-CCP antibodies are associated with the severity of the disease and erosion, they do not seem to have much linkage with extra-articular manifestations of RA.
评估长期类风湿关节炎（LsRA）患者中抗环瓜氨酸肽抗体（抗CCP）的频率及其与类风湿关节炎（RA）关节外表现的关系，此外比较早期RA（ERA）和LsRA组中抗CCP抗体的频率。
115例连续的RA患者因病程超过3年被纳入研究作为LsRA患者。39例连续的RA患者因病程小于3年被纳入研究作为ERA患者。另外，64名个体作为健康对照纳入研究以验证抗CCP抗体的特异性和敏感性。分别使用酶联免疫吸附测定试剂盒和标准比浊法评估抗CCP抗体和类风湿因子（RF）。关节外表现通过相关标准进行诊断。
发现有45例（39%）患者出现关节外表现。LsRA组和ERA组在关节外表现方面未发现显著差异。两组之间抗CCP抗体阳性患者数量和抗CCP抗体水平无差异。在LsRA组中，侵蚀与病程之间呈正相关（r = 0.24，p < 0.01），侵蚀与RF之间呈正相关（r = 0.29，p < 0.002），侵蚀与抗CCP抗体之间呈正相关（r = 0.21，p < 0.02）。在LsRA组中发现RF与抗CCP抗体之间呈正相关（r = 0.32，p < 0.0001），以及皮下结节与肺部受累之间呈正相关（r = 0.24，p < 0.008）。然而，无论是累积还是单独来看，抗CCP抗体阳性与关节外器官受累之间均未发现正相关。
尽管抗CCP抗体与疾病严重程度和侵蚀有关，但它们似乎与RA的关节外表现没有太多关联。
