Meymandi Manzumeh-Shamsi, Sepehri Gholamreza, Mobasher Mina
Physiology and Pharmacology Department, Kerman University of Medical Science, Kerman, Iran.
Pharmacol Biochem Behav. 2006 Sep;85(1):185-9. doi: 10.1016/j.pbb.2006.07.037. Epub 2006 Sep 18.
Whenever opioids as drug of choice result in inadequate analgesia, the combinational therapy would be the solution. In this study the co-administration of gabapentin with morphine is evaluated in acute model of pain. Therefore the antinociceptive effect of gabapentin (30 or 90 mg/kg, s.c.) and morphine (0.5, 1 or 3 mg/kg, s.c.) alone or in combination were measured by tail-flick test in intact adult male rats. Control rats received normal saline. Tail-flick latency time and Area Under Curve (AUC), as antinociception index were calculated for each groups. There was not any significant difference between the antinociceptive response of 0.5 mg/kg morphine and 30 mg/kg gabapentin as compared to controls, but co-administration of these subanalgesic doses increased significantly AUC as compared to morphine alone. The co-administration of gabapentin with analgesic doses of 1 and 3 mg/kg morphine had also increased significantly AUC. Therefore gabapentin enhanced the antinociceptive effect of both analgesic and subanalgesic doses of morphine in a dose dependent manner. In conclusion co-administration of gabapentin with low doses of morphine produced therapeutic analgesia which could have important clinical application.
每当阿片类药物作为首选药物导致镇痛不足时，联合治疗可能是解决办法。在本研究中，在急性疼痛模型中评估了加巴喷丁与吗啡的联合给药。因此，通过甩尾试验在成年雄性大鼠中测量了单独或联合使用加巴喷丁（30或90mg/kg，皮下注射）和吗啡（0.5、1或3mg/kg，皮下注射）的抗伤害感受作用。对照大鼠接受生理盐水。计算每组的甩尾潜伏期和曲线下面积（AUC）作为抗伤害感受指标。与对照组相比，0.5mg/kg吗啡和30mg/kg加巴喷丁的抗伤害感受反应没有显著差异，但与单独使用吗啡相比，这些亚镇痛剂量的联合给药显著增加了AUC。加巴喷丁与1mg/kg和3mg/kg镇痛剂量的吗啡联合给药也显著增加了AUC。因此，加巴喷丁以剂量依赖的方式增强了吗啡镇痛和亚镇痛剂量的抗伤害感受作用。总之，加巴喷丁与低剂量吗啡联合给药产生了治疗性镇痛，这可能具有重要的临床应用价值。
