Olt G, Berchuck A, Bast R C
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina 27710.
Obstet Gynecol Surv. 1990 Sep;45(9):570-7. doi: 10.1097/00006254-199009000-00002.
Human chorionic gonadotropin is a highly sensitive and specific tumor marker for gestational trophoblastic neoplasia that accurately reflects tumor volume and the clinical course of disease. In women with endodermal sinus tumors and embryonal carcinomas, alpha-fetoprotein usually is a reliable marker, and it accurately predicts the presence of yolk sac elements in mixed germ cell tumors. CA 125 is the most widely utilized tumor marker presently available for use in patients with epithelial ovarian cancer. It has utility in monitoring therapy and differentiating benign from malignant pelvic masses. Measurement of serial CA 125 levels in postmenopausal women may facilitate screening for occult early stage disease. In the future, monoclonal antibodies that recognize tumor-associated antigens may prove useful for radionuclide imaging.
人绒毛膜促性腺激素是妊娠滋养细胞肿瘤高度敏感且特异的肿瘤标志物，能准确反映肿瘤体积及疾病的临床进程。对于患有内胚窦瘤和胚胎癌的女性，甲胎蛋白通常是可靠的标志物，且能准确预测混合性生殖细胞肿瘤中卵黄囊成分的存在。CA 125是目前用于上皮性卵巢癌患者的应用最为广泛的肿瘤标志物。它在监测治疗以及鉴别盆腔肿块的良恶性方面具有作用。对绝经后女性连续测定CA 125水平可能有助于筛查隐匿性早期疾病。未来，识别肿瘤相关抗原的单克隆抗体可能被证明对放射性核素成像有用。
